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Title: Microfabricated injectable drug delivery system

Abstract

A microfabricated, fully integrated drug delivery system capable of secreting controlled dosages of multiple drugs over long periods of time (up to a year). The device includes a long and narrow shaped implant with a sharp leading edge for implantation under the skin of a human in a manner analogous to a sliver. The implant includes: 1) one or more micromachined, integrated, zero power, high and constant pressure generating osmotic engine; 2) low power addressable one-shot shape memory polymer (SMP) valves for switching on the osmotic engine, and for opening drug outlet ports; 3) microfabricated polymer pistons for isolating the pressure source from drug-filled microchannels; 4) multiple drug/multiple dosage capacity, and 5) anisotropically-etched, atomically-sharp silicon leading edge for penetrating the skin during implantation. The device includes an externally mounted controller for controlling on-board electronics which activates the SMP microvalves, etc. of the implant.

Inventors:
 [1];  [2]
  1. (Pleasanton, CA)
  2. (Oakland, CA)
Issue Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
OSTI Identifier:
874750
Patent Number(s):
6454759
Assignee:
The Regents of the University of California (Oakland, CA) LLNL
DOE Contract Number:  
W-7405-ENG-48
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
microfabricated; injectable; drug; delivery; integrated; capable; secreting; controlled; dosages; multiple; drugs; periods; time; device; narrow; shaped; implant; sharp; leading; edge; implantation; human; manner; analogous; sliver; micromachined; zero; power; constant; pressure; generating; osmotic; engine; addressable; one-shot; shape; memory; polymer; smp; valves; switching; outlet; ports; pistons; isolating; source; drug-filled; microchannels; drugmultiple; dosage; capacity; anisotropically-etched; atomically-sharp; silicon; penetrating; externally; mounted; controller; controlling; on-board; electronics; activates; microvalves; etc; leading edge; drug delivery; /604/424/

Citation Formats

Krulevitch, Peter A., and Wang, Amy W. Microfabricated injectable drug delivery system. United States: N. p., 2002. Web.
Krulevitch, Peter A., & Wang, Amy W. Microfabricated injectable drug delivery system. United States.
Krulevitch, Peter A., and Wang, Amy W. Tue . "Microfabricated injectable drug delivery system". United States. https://www.osti.gov/servlets/purl/874750.
@article{osti_874750,
title = {Microfabricated injectable drug delivery system},
author = {Krulevitch, Peter A. and Wang, Amy W.},
abstractNote = {A microfabricated, fully integrated drug delivery system capable of secreting controlled dosages of multiple drugs over long periods of time (up to a year). The device includes a long and narrow shaped implant with a sharp leading edge for implantation under the skin of a human in a manner analogous to a sliver. The implant includes: 1) one or more micromachined, integrated, zero power, high and constant pressure generating osmotic engine; 2) low power addressable one-shot shape memory polymer (SMP) valves for switching on the osmotic engine, and for opening drug outlet ports; 3) microfabricated polymer pistons for isolating the pressure source from drug-filled microchannels; 4) multiple drug/multiple dosage capacity, and 5) anisotropically-etched, atomically-sharp silicon leading edge for penetrating the skin during implantation. The device includes an externally mounted controller for controlling on-board electronics which activates the SMP microvalves, etc. of the implant.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2002},
month = {1}
}

Patent:

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