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Title: Method of filling a microchannel separation column

Abstract

A method for packing a stationary phase into a small diameter fluid passageway or flow channel. Capillary action is employed to distribute a stationary phase uniformly along both the length and diameter of the flow channel. The method disclosed here: 1) eliminates the need for high pressure pumps and fittings and the safety hazards associated therewith; 2) allows the use of readily available commercial microparticles, either coated or uncoated, as the stationary phase; 3) provides for different types of particles, different particle sizes, and different particle size distributions to be packed in sequence, or simultaneously; 4) eliminates the need for plugging the flow channel prior to adding the stationary phase to retain the packing particles; and 5) many capillaries can be filled simultaneously.

Inventors:
 [1]
  1. Livermore, CA
Issue Date:
Research Org.:
Sandia National Laboratories (SNL), Albuquerque, NM, and Livermore, CA (United States)
OSTI Identifier:
874699
Patent Number(s):
6444150
Assignee:
Sandia Corporation (Livermore, CA)
Patent Classifications (CPCs):
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
DOE Contract Number:  
AC04-94AL85000
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
method; filling; microchannel; separation; column; packing; stationary; phase; diameter; fluid; passageway; flow; channel; capillary; action; employed; distribute; uniformly; length; disclosed; eliminates; pressure; pumps; fittings; safety; hazards; associated; allows; readily; available; commercial; microparticles; coated; uncoated; provides; types; particles; particle; sizes; size; distributions; packed; sequence; simultaneously; plugging; prior; adding; retain; capillaries; filled; particle size; capillary action; pressure pump; fluid passage; fluid passageway; separation column; stationary phase; /264/210/

Citation Formats

Arnold, Don W. Method of filling a microchannel separation column. United States: N. p., 2002. Web.
Arnold, Don W. Method of filling a microchannel separation column. United States.
Arnold, Don W. Tue . "Method of filling a microchannel separation column". United States. https://www.osti.gov/servlets/purl/874699.
@article{osti_874699,
title = {Method of filling a microchannel separation column},
author = {Arnold, Don W},
abstractNote = {A method for packing a stationary phase into a small diameter fluid passageway or flow channel. Capillary action is employed to distribute a stationary phase uniformly along both the length and diameter of the flow channel. The method disclosed here: 1) eliminates the need for high pressure pumps and fittings and the safety hazards associated therewith; 2) allows the use of readily available commercial microparticles, either coated or uncoated, as the stationary phase; 3) provides for different types of particles, different particle sizes, and different particle size distributions to be packed in sequence, or simultaneously; 4) eliminates the need for plugging the flow channel prior to adding the stationary phase to retain the packing particles; and 5) many capillaries can be filled simultaneously.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2002},
month = {1}
}

Patent:

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