Microfabricated AC impedance sensor

Krulevitch, Peter; Ackler, Harold D; Becker, Frederick; Boser, Bernhard E; Eldredge, Adam B; Fuller, Christopher K; Gascoyne, Peter R. C.; Hamilton, Julie K; Swierkowski, Stefan P; Wang, Xiao-Bo

Title: Microfabricated AC impedance sensor

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Abstract

A microfabricated instrument for detecting and identifying cells and other particles based on alternating current (AC) impedance measurements. The microfabricated AC impedance sensor includes two critical elements: 1) a microfluidic chip, preferably of glass substrates, having at least one microchannel therein and with electrodes patterned on both substrates, and 2) electrical circuits that connect to the electrodes on the microfluidic chip and detect signals associated with particles traveling down the microchannels. These circuits enable multiple AC impedance measurements of individual particles at high throughput rates with sufficient resolution to identify different particle and cell types as appropriate for environmental detection and clinical diagnostic applications.

Inventors:

Krulevitch, Peter ^[1]; Ackler, Harold D ^[2]; Becker, Frederick ^[3]; Boser, Bernhard E ^[4]; Eldredge, Adam B ^[5]; Fuller, Christopher K ^[6]; Gascoyne, Peter R. C. ^[7]; Hamilton, Julie K ^[8]; Swierkowski, Stefan P ^[6]; Wang, Xiao-Bo ^[9]

Pleasanton, CA
Sunnyvale, CA
Houston, TX
Berkeley, CA
Austin, TX
Livermore, CA
Bellaire, TX
Tracy, CA
San Diego, CA

Issue Date:: 2002-01-01

Research Org.:: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)

OSTI Identifier:: 874672

Patent Number(s):: 6437551

Assignee:: The Regents of the University of California (Oakland, CA)

Patent Classifications (CPCs):: B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

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B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
B01L3/5027 - {by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G01N2015/129 - {measuring the ratio of AC/DC impedances}
G01N27/026 - {Dielectric impedance spectroscopy
G01N33/5438 - {Electrodes}

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DOE Contract Number:: W-7405-ENG-48

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: microfabricated; impedance; sensor; instrument; detecting; identifying; cells; particles; based; alternating; current; measurements; critical; elements; microfluidic; chip; glass; substrates; microchannel; electrodes; patterned; electrical; circuits; connect; detect; signals; associated; traveling; microchannels; enable; multiple; individual; throughput; rates; sufficient; resolution; identify; particle; cell; types; appropriate; environmental; detection; clinical; diagnostic; applications; alternating current; glass substrate; /324/436/

Citation Formats


                    Krulevitch, Peter, Ackler, Harold D, Becker, Frederick, Boser, Bernhard E, Eldredge, Adam B, Fuller, Christopher K, Gascoyne, Peter R. C., Hamilton, Julie K, Swierkowski, Stefan P, and Wang, Xiao-Bo. Microfabricated AC impedance sensor.  United States: N. p., 2002. 
        Web.

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                    Krulevitch, Peter, Ackler, Harold D, Becker, Frederick, Boser, Bernhard E, Eldredge, Adam B, Fuller, Christopher K, Gascoyne, Peter R. C., Hamilton, Julie K, Swierkowski, Stefan P, & Wang, Xiao-Bo. Microfabricated AC impedance sensor.  United States.

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                    Krulevitch, Peter, Ackler, Harold D, Becker, Frederick, Boser, Bernhard E, Eldredge, Adam B, Fuller, Christopher K, Gascoyne, Peter R. C., Hamilton, Julie K, Swierkowski, Stefan P, and Wang, Xiao-Bo. Tue .  
        "Microfabricated AC impedance sensor".  United States.  https://www.osti.gov/servlets/purl/874672.

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@article{osti_874672,

  title        = {Microfabricated AC impedance sensor},

  author       = {Krulevitch, Peter and Ackler, Harold D and Becker, Frederick and Boser, Bernhard E and Eldredge, Adam B and Fuller, Christopher K and Gascoyne, Peter R. C. and Hamilton, Julie K and Swierkowski, Stefan P and Wang, Xiao-Bo},

  abstractNote = {A microfabricated instrument for detecting and identifying cells and other particles based on alternating current (AC) impedance measurements. The microfabricated AC impedance sensor includes two critical elements: 1) a microfluidic chip, preferably of glass substrates, having at least one microchannel therein and with electrodes patterned on both substrates, and 2) electrical circuits that connect to the electrodes on the microfluidic chip and detect signals associated with particles traveling down the microchannels. These circuits enable multiple AC impedance measurements of individual particles at high throughput rates with sufficient resolution to identify different particle and cell types as appropriate for environmental detection and clinical diagnostic applications.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2002},

  month        = {1}

}

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