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Title: Micro-machined calorimetric biosensors

A method and apparatus are provided for detecting and monitoring micro-volumetric enthalpic changes caused by molecular reactions. Micro-machining techniques are used to create very small thermally isolated masses incorporating temperature-sensitive circuitry. The thermally isolated masses are provided with a molecular layer or coating, and the temperature-sensitive circuitry provides an indication when the molecules of the coating are involved in an enthalpic reaction. The thermally isolated masses may be provided singly or in arrays and, in the latter case, the molecular coatings may differ to provide qualitative and/or quantitative assays of a substance.
Inventors:
 [1];  [2];  [3];  [4];  [1];  [5];  [1];  [1]
  1. (Knoxville, TN)
  2. (Alcoa, TN)
  3. (Loudon, TN)
  4. (Plano, TX)
  5. (Powell, TN)
Issue Date:
OSTI Identifier:
874661
Assignee:
U T Battelle, LLC (Oak Ridge, TN) ORNL
Patent Number(s):
US 6436346
Contract Number:
AC05-96OR22464
Research Org:
LOCKHEED MARTIN ENERGY RES COR
Country of Publication:
United States
Language:
English
Subject:
micro-machined; calorimetric; biosensors; method; apparatus; provided; detecting; monitoring; micro-volumetric; enthalpic; changes; caused; molecular; reactions; micro-machining; techniques; create; thermally; isolated; masses; incorporating; temperature-sensitive; circuitry; layer; coating; provides; indication; molecules; involved; reaction; singly; arrays; latter; coatings; provide; qualitative; andor; quantitative; assays; substance; thermally isolate; /422/73/374/436/438/