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Title: Electrokinetic concentration of charged molecules

Abstract

A method for separating and concentrating charged species from uncharged or neutral species regardless of size differential. The method uses reversible electric field induced retention of charged species, that can include molecules and molecular aggregates such as dimers, polymers, multimers, colloids, micelles, and liposomes, in volumes and on surfaces of porous materials. The retained charged species are subsequently quantitatively removed from the porous material by a pressure driven flow that passes through the retention volume and is independent of direction thus, a multi-directional flow field is not required. Uncharged species pass through the system unimpeded thus effecting a complete separation of charged and uncharged species and making possible concentration factors greater than 1000-fold.

Inventors:
 [1];  [2];  [3];  [4]
  1. Berkeley, CA
  2. Castro Valley, CA
  3. Oakland, CA
  4. Livermore, CA
Issue Date:
Research Org.:
Sandia National Laboratories (SNL), Albuquerque, NM, and Livermore, CA (United States)
OSTI Identifier:
874635
Patent Number(s):
6428666
Assignee:
Sandia National Laboratories (Livermore, CA)
Patent Classifications (CPCs):
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01J - CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY
DOE Contract Number:  
AC04-94AL85000
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
electrokinetic; concentration; charged; molecules; method; separating; concentrating; species; uncharged; neutral; regardless; size; differential; reversible; electric; field; induced; retention; molecular; aggregates; dimers; polymers; multimers; colloids; micelles; liposomes; volumes; surfaces; porous; materials; retained; subsequently; quantitatively; removed; material; pressure; driven; flow; passes; volume; independent; direction; multi-directional; required; pass; unimpeded; effecting; complete; separation; factors; 1000-fold; electric field; flow field; charged species; field induced; /204/210/

Citation Formats

Singh, Anup K, Neyer, David W, Schoeniger, Joseph S, and Garguilo, Michael G. Electrokinetic concentration of charged molecules. United States: N. p., 2002. Web.
Singh, Anup K, Neyer, David W, Schoeniger, Joseph S, & Garguilo, Michael G. Electrokinetic concentration of charged molecules. United States.
Singh, Anup K, Neyer, David W, Schoeniger, Joseph S, and Garguilo, Michael G. Tue . "Electrokinetic concentration of charged molecules". United States. https://www.osti.gov/servlets/purl/874635.
@article{osti_874635,
title = {Electrokinetic concentration of charged molecules},
author = {Singh, Anup K and Neyer, David W and Schoeniger, Joseph S and Garguilo, Michael G},
abstractNote = {A method for separating and concentrating charged species from uncharged or neutral species regardless of size differential. The method uses reversible electric field induced retention of charged species, that can include molecules and molecular aggregates such as dimers, polymers, multimers, colloids, micelles, and liposomes, in volumes and on surfaces of porous materials. The retained charged species are subsequently quantitatively removed from the porous material by a pressure driven flow that passes through the retention volume and is independent of direction thus, a multi-directional flow field is not required. Uncharged species pass through the system unimpeded thus effecting a complete separation of charged and uncharged species and making possible concentration factors greater than 1000-fold.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2002},
month = {1}
}

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Works referenced in this record:

Solute retention in electrochromatography by electrically induced sorption
journal, May 1993


An Isotachophoretic Model of Counteracting Chromatographic Electrophoresis (CACE)
journal, July 1988


Recent progress in the electrochromatography of proteins
journal, July 1995


Interferences in solid-phase extraction using C-18 bonded porous silica cartridges
journal, July 1988


Solid phase versus solvent extraction of pesticides from water
journal, September 1986