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Title: Photoacoustic removal of occlusions from blood vessels

Abstract

Partial or total occlusions of fluid passages within the human body are removed by positioning an array of optical fibers in the passage and directing treatment radiation pulses along the fibers, one at a time, to generate a shock wave and hydrodynamics flows that strike and emulsify the occlusions. A preferred application is the removal of blood clots (thrombin and embolic) from small cerebral vessels to reverse the effects of an ischemic stroke. The operating parameters and techniques are chosen to minimize the amount of heating of the fragile cerebral vessel walls occurring during this photo acoustic treatment. One such technique is the optical monitoring of the existence of hydrodynamics flow generating vapor bubbles when they are expected to occur and stopping the heat generating pulses propagated along an optical fiber that is not generating such bubbles.

Inventors:
 [1];  [2];  [3];  [4];  [5];  [6]
  1. (Livermore, CA)
  2. (Danville, CA)
  3. (Berkeley, CA)
  4. (Orinda, CA)
  5. (Lafayette, CA)
  6. (San Francisco, CA)
Issue Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
OSTI Identifier:
874634
Patent Number(s):
6428531
Assignee:
The Regents of the University of California (Oakland, CA); Endovasix, Inc. (Belmont, CA) LLNL
DOE Contract Number:  
W-7405-ENG-48
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
photoacoustic; removal; occlusions; blood; vessels; partial; total; fluid; passages; human; removed; positioning; array; optical; fibers; passage; directing; treatment; radiation; pulses; time; generate; shock; wave; hydrodynamics; flows; strike; emulsify; application; clots; thrombin; embolic; cerebral; reverse; effects; ischemic; stroke; operating; parameters; techniques; chosen; minimize; amount; heating; fragile; vessel; walls; occurring; photo; acoustic; technique; monitoring; existence; flow; generating; vapor; bubbles; expected; occur; stopping; heat; propagated; fiber; optical fiber; vessel wall; fluid passage; blood vessel; radiation pulse; /606/128/607/

Citation Formats

Visuri, Steven R., Da Silva, Luiz B., Celliers, Peter M., London, Richard A., Maitland, IV, Duncan J., and Esch, Victor C. Photoacoustic removal of occlusions from blood vessels. United States: N. p., 2002. Web.
Visuri, Steven R., Da Silva, Luiz B., Celliers, Peter M., London, Richard A., Maitland, IV, Duncan J., & Esch, Victor C. Photoacoustic removal of occlusions from blood vessels. United States.
Visuri, Steven R., Da Silva, Luiz B., Celliers, Peter M., London, Richard A., Maitland, IV, Duncan J., and Esch, Victor C. Tue . "Photoacoustic removal of occlusions from blood vessels". United States. https://www.osti.gov/servlets/purl/874634.
@article{osti_874634,
title = {Photoacoustic removal of occlusions from blood vessels},
author = {Visuri, Steven R. and Da Silva, Luiz B. and Celliers, Peter M. and London, Richard A. and Maitland, IV, Duncan J. and Esch, Victor C.},
abstractNote = {Partial or total occlusions of fluid passages within the human body are removed by positioning an array of optical fibers in the passage and directing treatment radiation pulses along the fibers, one at a time, to generate a shock wave and hydrodynamics flows that strike and emulsify the occlusions. A preferred application is the removal of blood clots (thrombin and embolic) from small cerebral vessels to reverse the effects of an ischemic stroke. The operating parameters and techniques are chosen to minimize the amount of heating of the fragile cerebral vessel walls occurring during this photo acoustic treatment. One such technique is the optical monitoring of the existence of hydrodynamics flow generating vapor bubbles when they are expected to occur and stopping the heat generating pulses propagated along an optical fiber that is not generating such bubbles.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2002},
month = {1}
}

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