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Title: Organo luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes

A semiconductor nanocrystal compound is described capable of linking to an affinity molecule. The compound comprises (1) a semiconductor nanocrystal capable of emitting electromagnetic radiation and/or absorbing energy, and/or scattering or diffracting electromagnetic radiation--when excited by an electromagnetic radiation source or a particle beam; and (2) at least one linking agent, having a first portion linked to the semiconductor nanocrystal and a second portion capable of linking to an affity molecule. The compound is linked to an affinity molecule to form a semiconductor nanocrystal probe capable of bonding with a detectable substance. Subsequent exposure to excitation energy will excite the semiconductor nanocrystal in he probe, causing the emission of electromagnetic radiation. Further described are processes for respectively: making the semiconductor nanocrystal compound; making the semiconductor nanocrystal probe; and using the probe to determine the presence of a detectable substance in a material.
Inventors:
 [1];  [2];  [3]
  1. (Pinole, CA)
  2. (Albany, CA)
  3. (Oakland, CA)
Issue Date:
OSTI Identifier:
874612
Assignee:
The Regents of the University of California (Oakland, CA) LBNL
Patent Number(s):
US 6423551
Contract Number:
AC03-76SF00098
Research Org:
University of California
Country of Publication:
United States
Language:
English
Subject:
organo; luminescent; semiconductor; nanocrystal; probes; biological; applications; process; compound; described; capable; linking; affinity; molecule; emitting; electromagnetic; radiation; andor; absorbing; energy; scattering; diffracting; radiation-when; excited; source; particle; beam; agent; portion; linked; affity; form; probe; bonding; detectable; substance; subsequent; exposure; excitation; excite; causing; emission; processes; determine; presence; material; electromagnetic radiation; particle beam; radiation source; semiconductor nanocrystal; /436/424/428/

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