Polynucleotides encoding TRF1 binding proteins

Campisi, Judith; Kim, Sahn-Ho

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Title: Polynucleotides encoding TRF1 binding proteins

Abstract

The present invention provides a novel telomere associated protein (Trf1-interacting nuclear protein 2 "Tin2") that hinders the binding of Trf1 to its specific telomere repeat sequence and mediates the formation of a Tin2-Trf1-telomeric DNA complex that limits telomerase access to the telomere. Also included are the corresponding nucleic acids that encode the Tin2 of the present invention, as well as mutants of Tin2. Methods of making, purifying and using Tin2 of the present invention are described. In addition, drug screening assays to identify drugs that mimic and/or complement the effect of Tin2 are presented.

Inventors:

Campisi, Judith ^[1]; Kim, Sahn-Ho ^[2]

Berkeley, CA
Albany, CA

Issue Date:: 2002-01-01

Research Org.:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

OSTI Identifier:: 874537

Patent Number(s):: 6409648

Assignee:: The Regents of the University of California (Oakland, CA)

Patent Classifications (CPCs):: C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES

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C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
C07K14/47 - from mammals

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DOE Contract Number:: AC03-76SF00098

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: polynucleotides; encoding; trf1; binding; proteins; provides; novel; telomere; associated; protein; trf1-interacting; nuclear; tin2; hinders; specific; repeat; sequence; mediates; formation; tin2-trf1-telomeric; dna; complex; limits; telomerase; access; included; nucleic; acids; encode; mutants; methods; purifying; described; addition; drug; screening; assays; identify; drugs; mimic; andor; complement; effect; nucleic acid; binding protein; repeat sequence; /435/999/

Citation Formats


                    Campisi, Judith, and Kim, Sahn-Ho. Polynucleotides encoding TRF1 binding proteins.  United States: N. p., 2002. 
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                    Campisi, Judith, & Kim, Sahn-Ho. Polynucleotides encoding TRF1 binding proteins.  United States.

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                    Campisi, Judith, and Kim, Sahn-Ho. Tue .  
        "Polynucleotides encoding TRF1 binding proteins".  United States.  https://www.osti.gov/servlets/purl/874537.

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@article{osti_874537,

  title        = {Polynucleotides encoding TRF1 binding proteins},

  author       = {Campisi, Judith and Kim, Sahn-Ho},

  abstractNote = {The present invention provides a novel telomere associated protein (Trf1-interacting nuclear protein 2 "Tin2") that hinders the binding of Trf1 to its specific telomere repeat sequence and mediates the formation of a Tin2-Trf1-telomeric DNA complex that limits telomerase access to the telomere. Also included are the corresponding nucleic acids that encode the Tin2 of the present invention, as well as mutants of Tin2. Methods of making, purifying and using Tin2 of the present invention are described. In addition, drug screening assays to identify drugs that mimic and/or complement the effect of Tin2 are presented.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2002},

  month        = {1}

}

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Similar Records

Title: Polynucleotides encoding TRF1 binding proteins

Abstract

Citation Formats

Identification of a nonprocessive telomerase activity from mouse cells. journal, February 1993

In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs journal, March 1990

A mutant with a defect in telomere elongation leads to senescence in yeast journal, May 1989

Antisense oligonucleotides for therapeutic intervention journal, December 1991

Ribozymes and Their Medical Implications journal, November 1988

Identification of a specific telomere terminal transferase activity in tetrahymena extracts journal, December 1985

The telomere hypothesis of cellular aging journal, July 1992

The serial cultivation of human diploid cell strains journal, December 1961

New telomere formation after developmentally regulated chromosomal breakage during the process of chromatin diminution in ascaris lumbricoides journal, November 1991

Variability at the Telomeres of the Human X/Y Pseudoautosomal Region journal, January 1986

Telomere length predicts replicative capacity of human fibroblasts. journal, November 1992

The RNA component of human telomerase journal, September 1995

Telomere loss and cancer journal, March 1991

Telomerase RNAs of different ciliates have a common secondary structure and a permuted template. journal, August 1994

Telomerases journal, June 1992

Telomerase and Telomere-length Regulation: Lessons from Small Eukaryotes to Mammals journal, January 1993

Position effect at S. cerevisiae telomeres: Reversible repression of Pol II transcription journal, November 1990

Telomerase activity in normal leukocytes and in hematologic malignancies journal, May 1995

Strict relationship between dialyzed serum concentration and cellular life span in vitro journal, October 1979

Specific association of human telomerase activity with immortal cells and cancer journal, December 1994

TLC1: template RNA component of Saccharomyces cerevisiae telomerase journal, October 1994

Telomeres shorten during ageing of human fibroblasts journal, May 1990

Telomere telomere recombination provides an express pathway for telomere acquisition journal, May 1990

A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis journal, January 1989

Recognition of a chromosome truncation site associated with α-thalassaemia by human telomerase journal, October 1991

Length of Telomeric Repeats in Neuroblastoma: Correlation with Prognosis and Other Biological Characteristics journal, February 1992

Telomerase is processive. journal, September 1991

A truncated human chromosome 16 associated with α thalassaemia is stabilized by addition of telomeric repeat (TTAGGG)n journal, August 1990

Telomere G-strand structure and function analyzed by chemical protection, base analog substitution, and utilization by telomerase in vitro journal, January 1990

Restoration of telomeres in human papillomavirus-immortalized human anogenital epithelial cells. journal, February 1994

Genetic disease detection and DNA amplification using cloned thermostable ligase. journal, January 1991

The effects of nucleoside analogs on telomerase and telomeres in Tetrahymena journal, January 1994

Telomeres, telomerase and senescence journal, August 1990

Stabilization of short telomeres and telomerase activity accompany immortalization of Epstein-Barr virus-transformed human B lymphocytes. journal, January 1994

Extensive telomere repeat arrays in mouse are hypervariable journal, January 1990

Transcription-based amplification system and detection of amplified human immunodeficiency virus type 1 with a bead-based sandwich hybridization format. journal, February 1989

Tying up the loose ends journal, March 1990

Ribozymes and their medical implications journal, November 1988

Developmentally programmed healing of chromosomes by telomerase in tetrahymena journal, November 1991

Loss of Telomeric dna During Aging may Predispose Cells to Cancer (Review) journal, October 1993

Telomerase activity in human ovarian carcinoma. journal, April 1994

The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats journal, November 1989

[5] Media and growth requirements book, January 1979

The telomere terminal transferase of tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity journal, December 1987

The beginning of the ends journal, January 1989

Chromosome first aid journal, November 1991

Improved telomere detection using a telomere repeat probe (TTAGGG) n generated by PCR journal, January 1991

Cloning and expression of genes for the Oxytricha telomere-binding protein: Specific subunit interactions in the telomeric complex journal, November 1991

Telomerase primer specificity and chromosome healing journal, October 1991

Recognition and elongation of telomeres by telomerase journal, January 1989

Characterization and organization of DNA sequences adjacent to the human telomere associated repeat (TTAGGG) n journal, January 1990

Functional evidence for an RNA template in telomerase journal, February 1990

Mechanisms underlying telomere repeat turnover, revealed by hypervariable variant repeat distribution patterns in the human Xp/Yp telomere. journal, November 1995

Immortal's Enzyme journal, July 1994

Thein vivo application of ribozymes journal, January 1990

Telomere loss: mitotic clock or genetic time bomb? journal, March 1991

Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. journal, May 1992

Replicative senescence: the human fibroblast comes of age journal, September 1990

A conserved secondary structure for telomerase RNA journal, October 1991

The Molecular Structure of Centromeres and Telomeres journal, June 1984

Intraclonal variation in proliferative potential of human diploid fibroblasts: stochastic mechanism for cellular aging journal, January 1980

Amino acid sequence of the human protein synthesis initiation factor eIF-4 gamma journal, November 1992

Structure and function of telomeres journal, April 1991

A theory of marginotomy journal, September 1973

Inhibition of telomerase by G-quartet DMA structures journal, April 1991

Identification of a nonprocessive telomerase activity from mouse cells.
journal, February 1993

In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs
journal, March 1990

A mutant with a defect in telomere elongation leads to senescence in yeast
journal, May 1989

Antisense oligonucleotides for therapeutic intervention
journal, December 1991

Ribozymes and Their Medical Implications
journal, November 1988

Identification of a specific telomere terminal transferase activity in tetrahymena extracts
journal, December 1985

The telomere hypothesis of cellular aging
journal, July 1992

The serial cultivation of human diploid cell strains
journal, December 1961

New telomere formation after developmentally regulated chromosomal breakage during the process of chromatin diminution in ascaris lumbricoides
journal, November 1991

Variability at the Telomeres of the Human X/Y Pseudoautosomal Region
journal, January 1986

Telomere length predicts replicative capacity of human fibroblasts.
journal, November 1992

The RNA component of human telomerase
journal, September 1995

Telomere loss and cancer
journal, March 1991

Telomerase RNAs of different ciliates have a common secondary structure and a permuted template.
journal, August 1994

Telomerases
journal, June 1992

Telomerase and Telomere-length Regulation: Lessons from Small Eukaryotes to Mammals
journal, January 1993

Position effect at S. cerevisiae telomeres: Reversible repression of Pol II transcription
journal, November 1990

Telomerase activity in normal leukocytes and in hematologic malignancies
journal, May 1995

Strict relationship between dialyzed serum concentration and cellular life span in vitro
journal, October 1979

Specific association of human telomerase activity with immortal cells and cancer
journal, December 1994

TLC1: template RNA component of Saccharomyces cerevisiae telomerase
journal, October 1994

Telomeres shorten during ageing of human fibroblasts
journal, May 1990

Telomere telomere recombination provides an express pathway for telomere acquisition
journal, May 1990

A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis
journal, January 1989

Recognition of a chromosome truncation site associated with α-thalassaemia by human telomerase
journal, October 1991

Length of Telomeric Repeats in Neuroblastoma: Correlation with Prognosis and Other Biological Characteristics
journal, February 1992

Telomerase is processive.
journal, September 1991

A truncated human chromosome 16 associated with α thalassaemia is stabilized by addition of telomeric repeat (TTAGGG)n
journal, August 1990

Telomere G-strand structure and function analyzed by chemical protection, base analog substitution, and utilization by telomerase in vitro
journal, January 1990

Restoration of telomeres in human papillomavirus-immortalized human anogenital epithelial cells.
journal, February 1994

Genetic disease detection and DNA amplification using cloned thermostable ligase.
journal, January 1991

The effects of nucleoside analogs on telomerase and telomeres in Tetrahymena
journal, January 1994

Telomeres, telomerase and senescence
journal, August 1990

Stabilization of short telomeres and telomerase activity accompany immortalization of Epstein-Barr virus-transformed human B lymphocytes.
journal, January 1994

Extensive telomere repeat arrays in mouse are hypervariable
journal, January 1990

Transcription-based amplification system and detection of amplified human immunodeficiency virus type 1 with a bead-based sandwich hybridization format.
journal, February 1989

Tying up the loose ends
journal, March 1990

Ribozymes and their medical implications
journal, November 1988

Developmentally programmed healing of chromosomes by telomerase in tetrahymena
journal, November 1991

Loss of Telomeric dna During Aging may Predispose Cells to Cancer (Review)
journal, October 1993

Telomerase activity in human ovarian carcinoma.
journal, April 1994

The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats
journal, November 1989

[5] Media and growth requirements
book, January 1979

The telomere terminal transferase of tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity
journal, December 1987

The beginning of the ends
journal, January 1989

Chromosome first aid
journal, November 1991

Improved telomere detection using a telomere repeat probe (TTAGGG) _n generated by PCR
journal, January 1991

Cloning and expression of genes for the Oxytricha telomere-binding protein: Specific subunit interactions in the telomeric complex
journal, November 1991

Telomerase primer specificity and chromosome healing
journal, October 1991

Recognition and elongation of telomeres by telomerase
journal, January 1989

Characterization and organization of DNA sequences adjacent to the human telomere associated repeat (TTAGGG) _n
journal, January 1990

Functional evidence for an RNA template in telomerase
journal, February 1990

Mechanisms underlying telomere repeat turnover, revealed by hypervariable variant repeat distribution patterns in the human Xp/Yp telomere.
journal, November 1995

Immortal's Enzyme
journal, July 1994

Thein vivo application of ribozymes
journal, January 1990

Telomere loss: mitotic clock or genetic time bomb?
journal, March 1991

Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.
journal, May 1992

Replicative senescence: the human fibroblast comes of age
journal, September 1990

A conserved secondary structure for telomerase RNA
journal, October 1991

The Molecular Structure of Centromeres and Telomeres
journal, June 1984

Intraclonal variation in proliferative potential of human diploid fibroblasts: stochastic mechanism for cellular aging
journal, January 1980

Amino acid sequence of the human protein synthesis initiation factor eIF-4 gamma
journal, November 1992

Structure and function of telomeres
journal, April 1991

A theory of marginotomy
journal, September 1973

Inhibition of telomerase by G-quartet DMA structures
journal, April 1991