skip to main content
DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Polynucleotides encoding TRF1 binding proteins

Abstract

The present invention provides a novel telomere associated protein (Trf1-interacting nuclear protein 2 "Tin2") that hinders the binding of Trf1 to its specific telomere repeat sequence and mediates the formation of a Tin2-Trf1-telomeric DNA complex that limits telomerase access to the telomere. Also included are the corresponding nucleic acids that encode the Tin2 of the present invention, as well as mutants of Tin2. Methods of making, purifying and using Tin2 of the present invention are described. In addition, drug screening assays to identify drugs that mimic and/or complement the effect of Tin2 are presented.

Inventors:
 [1];  [2]
  1. (Berkeley, CA)
  2. (Albany, CA)
Issue Date:
Research Org.:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA
OSTI Identifier:
874537
Patent Number(s):
6409648
Assignee:
The Regents of the University of California (Oakland, CA) LBNL
DOE Contract Number:  
AC03-76SF00098
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
polynucleotides; encoding; trf1; binding; proteins; provides; novel; telomere; associated; protein; trf1-interacting; nuclear; tin2; hinders; specific; repeat; sequence; mediates; formation; tin2-trf1-telomeric; dna; complex; limits; telomerase; access; included; nucleic; acids; encode; mutants; methods; purifying; described; addition; drug; screening; assays; identify; drugs; mimic; andor; complement; effect; nucleic acid; binding protein; repeat sequence; /435/999/

Citation Formats

Campisi, Judith, and Kim, Sahn-Ho. Polynucleotides encoding TRF1 binding proteins. United States: N. p., 2002. Web.
Campisi, Judith, & Kim, Sahn-Ho. Polynucleotides encoding TRF1 binding proteins. United States.
Campisi, Judith, and Kim, Sahn-Ho. Tue . "Polynucleotides encoding TRF1 binding proteins". United States. https://www.osti.gov/servlets/purl/874537.
@article{osti_874537,
title = {Polynucleotides encoding TRF1 binding proteins},
author = {Campisi, Judith and Kim, Sahn-Ho},
abstractNote = {The present invention provides a novel telomere associated protein (Trf1-interacting nuclear protein 2 "Tin2") that hinders the binding of Trf1 to its specific telomere repeat sequence and mediates the formation of a Tin2-Trf1-telomeric DNA complex that limits telomerase access to the telomere. Also included are the corresponding nucleic acids that encode the Tin2 of the present invention, as well as mutants of Tin2. Methods of making, purifying and using Tin2 of the present invention are described. In addition, drug screening assays to identify drugs that mimic and/or complement the effect of Tin2 are presented.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2002},
month = {1}
}

Patent:

Save / Share: