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Title: 4-fluoroalkyl-3-halophenyl nortropanes

Abstract

A series of compounds in the 4-fluoroalkyl-3-halophenyl nortropanes family are described as diagnostic and therapeutic agents for diseases associated with serotonin transporter dysfunction. These compounds bind to serotonin transporter protein with high affinity and selectivity. The invention provides methods of synthesis which incorporate radioisotopic halogens at a last step which permit high radiochemical yield and maximum usable product life. The radiolabeled compounds of the invention are useful as imaging agents for visualizing the location and density of serotonin transporter by PET and SPECT imaging.

Inventors:
 [1];  [2]
  1. (Atlanta, GA)
  2. (Indianapolis, IN)
Issue Date:
Research Org.:
Oak Ridge National Laboratory (ORNL), Oak Ridge, TN
OSTI Identifier:
874483
Patent Number(s):
6399042
Application Number:
10/558916
Assignee:
Emory University (Atlanta, GA) ORNL
DOE Contract Number:  
FG02-97ER62367
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
4-fluoroalkyl-3-halophenyl; nortropanes; series; compounds; family; described; diagnostic; therapeutic; agents; diseases; associated; serotonin; transporter; dysfunction; bind; protein; affinity; selectivity; provides; methods; synthesis; incorporate; radioisotopic; halogens; step; permit; radiochemical; yield; maximum; usable; product; life; radiolabeled; useful; imaging; visualizing; location; density; pet; provides methods; therapeutic agent; /424/999/

Citation Formats

Goodman, Mark M., and Chen, Ping. 4-fluoroalkyl-3-halophenyl nortropanes. United States: N. p., 2002. Web.
Goodman, Mark M., & Chen, Ping. 4-fluoroalkyl-3-halophenyl nortropanes. United States.
Goodman, Mark M., and Chen, Ping. Tue . "4-fluoroalkyl-3-halophenyl nortropanes". United States. https://www.osti.gov/servlets/purl/874483.
@article{osti_874483,
title = {4-fluoroalkyl-3-halophenyl nortropanes},
author = {Goodman, Mark M. and Chen, Ping},
abstractNote = {A series of compounds in the 4-fluoroalkyl-3-halophenyl nortropanes family are described as diagnostic and therapeutic agents for diseases associated with serotonin transporter dysfunction. These compounds bind to serotonin transporter protein with high affinity and selectivity. The invention provides methods of synthesis which incorporate radioisotopic halogens at a last step which permit high radiochemical yield and maximum usable product life. The radiolabeled compounds of the invention are useful as imaging agents for visualizing the location and density of serotonin transporter by PET and SPECT imaging.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2002},
month = {6}
}

Patent:

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