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Title: Transition metal-catalyzed process for addition of amines to carbon-carbon double bonds

Abstract

The present invention is directed to a process for addition of amines to carbon-carbon double bonds in a substrate, comprising: reacting an amine with a compound containing at least one carbon-carbon double bond in the presence a transition metal catalyst under reaction conditions effective to form a product having a covalent bond between the amine and a carbon atom of the former carbon-carbon double bond. The transition metal catalyst comprises a Group 8 metal and a ligand containing one or more 2-electron donor atoms. The present invention is also directed to enantioselective reactions of amine compounds with compounds containing carbon-carbon double bonds, and a calorimetric assay to evaluate potential catalysts in these reactions.

Inventors:
 [1];  [2];  [3]
  1. (Durham, CT)
  2. (Chatham, NJ)
  3. (New Haven, CT)
Issue Date:
Research Org.:
Yale University (New Haven, CT)
OSTI Identifier:
874407
Patent Number(s):
6384282
Assignee:
Yale University (New Haven, CT) CHO
DOE Contract Number:  
FG02-96ER14678
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
transition; metal-catalyzed; process; addition; amines; carbon-carbon; double; bonds; directed; substrate; comprising; reacting; amine; compound; containing; bond; presence; metal; catalyst; reaction; conditions; effective; form; product; covalent; carbon; atom; former; ligand; 2-electron; donor; atoms; enantioselective; reactions; compounds; calorimetric; assay; evaluate; potential; catalysts; transition metal; reaction conditions; double bond; /999/356/

Citation Formats

Hartwig, John F., Kawatsura, Motoi, and Loeber, Oliver. Transition metal-catalyzed process for addition of amines to carbon-carbon double bonds. United States: N. p., 2002. Web.
Hartwig, John F., Kawatsura, Motoi, & Loeber, Oliver. Transition metal-catalyzed process for addition of amines to carbon-carbon double bonds. United States.
Hartwig, John F., Kawatsura, Motoi, and Loeber, Oliver. Tue . "Transition metal-catalyzed process for addition of amines to carbon-carbon double bonds". United States. https://www.osti.gov/servlets/purl/874407.
@article{osti_874407,
title = {Transition metal-catalyzed process for addition of amines to carbon-carbon double bonds},
author = {Hartwig, John F. and Kawatsura, Motoi and Loeber, Oliver},
abstractNote = {The present invention is directed to a process for addition of amines to carbon-carbon double bonds in a substrate, comprising: reacting an amine with a compound containing at least one carbon-carbon double bond in the presence a transition metal catalyst under reaction conditions effective to form a product having a covalent bond between the amine and a carbon atom of the former carbon-carbon double bond. The transition metal catalyst comprises a Group 8 metal and a ligand containing one or more 2-electron donor atoms. The present invention is also directed to enantioselective reactions of amine compounds with compounds containing carbon-carbon double bonds, and a calorimetric assay to evaluate potential catalysts in these reactions.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2002},
month = {1}
}

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