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Title: Method for measuring changes in light absorption of highly scattering media

Abstract

The noninvasive measurement of variations in absorption that are due to changes in concentrations of biochemically relevant compounds in tissue is important in many clinical settings. One problem with such measurements is that the pathlength traveled by the collected light through the tissue depends on the scattering properties of the tissue. It is demonstrated, using both Monte Carlo simulations and experimental measurements, that for an appropriate separation between light-delivery and light-collection fibers, the pathlength of the collected photons is insensitive to scattering parameters for the range of parameters typically found in tissue. This is important for developing rapid, noninvasive, inexpensive, and accurate methods for measuring absorption changes in tissue.

Inventors:
 [1];  [1];  [1]
  1. Los Alamos, NM
Issue Date:
Research Org.:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
OSTI Identifier:
874391
Patent Number(s):
6381018
Assignee:
The Regents of the University of California (Los Alamos, NM)
Patent Classifications (CPCs):
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
DOE Contract Number:  
W-7405-ENG-36
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
method; measuring; changes; light; absorption; highly; scattering; media; noninvasive; measurement; variations; due; concentrations; biochemically; relevant; compounds; tissue; clinical; settings; measurements; pathlength; traveled; collected; depends; properties; demonstrated; monte; carlo; simulations; experimental; appropriate; separation; light-delivery; light-collection; fibers; photons; insensitive; parameters; range; typically; found; developing; rapid; inexpensive; accurate; methods; monte carlo; scattering media; highly scattering; measuring changes; noninvasive measurement; /356/600/

Citation Formats

Bigio, Irving J, Johnson, Tamara M, and Mourant, Judith R. Method for measuring changes in light absorption of highly scattering media. United States: N. p., 2002. Web.
Bigio, Irving J, Johnson, Tamara M, & Mourant, Judith R. Method for measuring changes in light absorption of highly scattering media. United States.
Bigio, Irving J, Johnson, Tamara M, and Mourant, Judith R. Tue . "Method for measuring changes in light absorption of highly scattering media". United States. https://www.osti.gov/servlets/purl/874391.
@article{osti_874391,
title = {Method for measuring changes in light absorption of highly scattering media},
author = {Bigio, Irving J and Johnson, Tamara M and Mourant, Judith R},
abstractNote = {The noninvasive measurement of variations in absorption that are due to changes in concentrations of biochemically relevant compounds in tissue is important in many clinical settings. One problem with such measurements is that the pathlength traveled by the collected light through the tissue depends on the scattering properties of the tissue. It is demonstrated, using both Monte Carlo simulations and experimental measurements, that for an appropriate separation between light-delivery and light-collection fibers, the pathlength of the collected photons is insensitive to scattering parameters for the range of parameters typically found in tissue. This is important for developing rapid, noninvasive, inexpensive, and accurate methods for measuring absorption changes in tissue.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2002},
month = {1}
}

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Works referenced in this record:

Optimal probe geometry for near-infrared spectroscopy of biological tissue
journal, January 1997


Non-invasive measurement of chemotherapy drug concentrations in tissue: preliminary demonstrations of in vivo measurements
journal, January 1999