Spectroscopic diagnostics for bacteria in biologic sample
Abstract
A method to analyze and diagnose specific bacteria in a biologic sample using spectroscopy is disclosed. The method includes obtaining the spectra of a biologic sample of a non-infected patient for use as a reference, subtracting the reference from the spectra of an infected sample, and comparing the fingerprint regions of the resulting differential spectrum with reference spectra of bacteria in saline. Using this diagnostic technique, specific bacteria can be identified sooner and without culturing, bacteria-specific antibiotics can be prescribed sooner, resulting in decreased likelihood of antibiotic resistance and an overall reduction of medical costs.
- Inventors:
-
- Atlanta, GA
- Somerville, MA
- Issue Date:
- Research Org.:
- Georgia Tech Research Corp. (Atlanta, GA); Boston Medical Center Corp. (Boston, MA)
- OSTI Identifier:
- 874388
- Patent Number(s):
- 6379920
- Assignee:
- Georgia Tech Research Corp. (Atlanta, GA); Boston Medical Center Corp. (Boston, MA)
- Patent Classifications (CPCs):
-
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
- DOE Contract Number:
- FG02-97ER14799
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- spectroscopic; diagnostics; bacteria; biologic; sample; method; analyze; diagnose; specific; spectroscopy; disclosed; obtaining; spectra; non-infected; patient; reference; subtracting; infected; comparing; fingerprint; regions; resulting; differential; spectrum; saline; diagnostic; technique; identified; sooner; culturing; bacteria-specific; antibiotics; prescribed; decreased; likelihood; antibiotic; resistance; overall; reduction; medical; costs; /435/
Citation Formats
El-Sayed, Mostafa A, and El-Sayed, Ivan H. Spectroscopic diagnostics for bacteria in biologic sample. United States: N. p., 2002.
Web.
El-Sayed, Mostafa A, & El-Sayed, Ivan H. Spectroscopic diagnostics for bacteria in biologic sample. United States.
El-Sayed, Mostafa A, and El-Sayed, Ivan H. Tue .
"Spectroscopic diagnostics for bacteria in biologic sample". United States. https://www.osti.gov/servlets/purl/874388.
@article{osti_874388,
title = {Spectroscopic diagnostics for bacteria in biologic sample},
author = {El-Sayed, Mostafa A and El-Sayed, Ivan H},
abstractNote = {A method to analyze and diagnose specific bacteria in a biologic sample using spectroscopy is disclosed. The method includes obtaining the spectra of a biologic sample of a non-infected patient for use as a reference, subtracting the reference from the spectra of an infected sample, and comparing the fingerprint regions of the resulting differential spectrum with reference spectra of bacteria in saline. Using this diagnostic technique, specific bacteria can be identified sooner and without culturing, bacteria-specific antibiotics can be prescribed sooner, resulting in decreased likelihood of antibiotic resistance and an overall reduction of medical costs.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2002},
month = {1}
}
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Works referenced in this record:
Noninvasive Optical Diagnosis of Bacteria Causing Otitis Media
journal, January 1994
- Werkhaven, J. A.; Reinisch, L.; Sorrell, M.
- The Laryngoscope, Vol. 104, Issue 3