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Title: Opto-acoustic transducer for medical applications

Abstract

This invention is an optically activated transducer for generating acoustic vibrations in a biological medium. The transducer is located at the end of a fiber optic which may be located within a catheter. Energy for operating the transducer is provided optically by laser light transmitted through the fiber optic to the transducer. Pulsed laser light is absorbed in the working fluid of the transducer to generate a thermal pressure and consequent adiabatic expansion of the transducer head such that it does work against the ambient medium. The transducer returns to its original state by a process of thermal cooling. The motion of the transducer within the ambient medium couples acoustic energy into the medium. By pulsing the laser at a high repetition rate (which may vary from CW to 100 kHz) an ultrasonic radiation field can be established locally in the medium. This method of producing ultrasonic vibrations can be used in vivo for the treatment of stroke-related conditions in humans, particularly for dissolving thrombus. The catheter may also incorporate anti-thrombolytic drug treatments as an adjunct therapy and it may be operated in conjunction with ultrasonic detection equipment for imaging and feedback control.

Inventors:
 [1];  [2];  [3];  [1];  [4];  [1];  [5];  [6];  [7]
  1. Livermore, CA
  2. Berkeley, CA
  3. Danville, CA
  4. Orinda, CA
  5. Moss Beach, CA
  6. Pleasanton, CA
  7. Walnut Creek, CA
Issue Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
OSTI Identifier:
874380
Patent Number(s):
6379325
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS
DOE Contract Number:  
W-7405-ENG-48
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
opto-acoustic; transducer; medical; applications; optically; activated; generating; acoustic; vibrations; biological; medium; located; fiber; optic; catheter; energy; operating; provided; laser; light; transmitted; pulsed; absorbed; fluid; generate; thermal; pressure; consequent; adiabatic; expansion; head; ambient; returns; original; process; cooling; motion; couples; pulsing; repetition; rate; cw; 100; khz; ultrasonic; radiation; field; established; locally; method; producing; vivo; treatment; stroke-related; conditions; humans; dissolving; thrombus; incorporate; anti-thrombolytic; drug; treatments; adjunct; therapy; operated; conjunction; detection; equipment; imaging; feedback; control; fiber optic; laser light; pulsed laser; repetition rate; light transmitted; acoustic vibration; /604/606/

Citation Formats

Benett, William, Celliers, Peter, Da Silva, Luiz, Glinsky, Michael, London, Richard, Maitland, Duncan, Matthews, Dennis, Krulevich, Peter, and Lee, Abraham. Opto-acoustic transducer for medical applications. United States: N. p., 2002. Web.
Benett, William, Celliers, Peter, Da Silva, Luiz, Glinsky, Michael, London, Richard, Maitland, Duncan, Matthews, Dennis, Krulevich, Peter, & Lee, Abraham. Opto-acoustic transducer for medical applications. United States.
Benett, William, Celliers, Peter, Da Silva, Luiz, Glinsky, Michael, London, Richard, Maitland, Duncan, Matthews, Dennis, Krulevich, Peter, and Lee, Abraham. Tue . "Opto-acoustic transducer for medical applications". United States. https://www.osti.gov/servlets/purl/874380.
@article{osti_874380,
title = {Opto-acoustic transducer for medical applications},
author = {Benett, William and Celliers, Peter and Da Silva, Luiz and Glinsky, Michael and London, Richard and Maitland, Duncan and Matthews, Dennis and Krulevich, Peter and Lee, Abraham},
abstractNote = {This invention is an optically activated transducer for generating acoustic vibrations in a biological medium. The transducer is located at the end of a fiber optic which may be located within a catheter. Energy for operating the transducer is provided optically by laser light transmitted through the fiber optic to the transducer. Pulsed laser light is absorbed in the working fluid of the transducer to generate a thermal pressure and consequent adiabatic expansion of the transducer head such that it does work against the ambient medium. The transducer returns to its original state by a process of thermal cooling. The motion of the transducer within the ambient medium couples acoustic energy into the medium. By pulsing the laser at a high repetition rate (which may vary from CW to 100 kHz) an ultrasonic radiation field can be established locally in the medium. This method of producing ultrasonic vibrations can be used in vivo for the treatment of stroke-related conditions in humans, particularly for dissolving thrombus. The catheter may also incorporate anti-thrombolytic drug treatments as an adjunct therapy and it may be operated in conjunction with ultrasonic detection equipment for imaging and feedback control.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2002},
month = {1}
}

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Works referenced in this record:

Effects of Shielded or Unshielded Laser and Electrohydraulic Lithotripsy on Rabbit Bladder
journal, April 1990


Gallstone lithotripsy: relevant physical principles and technical issues.
journal, February 1991


Shock Waves in Solids
journal, May 1969


Noncontact tissue ablation by Holmium: YSGG laser pulses in blood
journal, January 1991