Method for analyzing nucleic acids by means of a substrate having a microchannel structure containing immobilized nucleic acid probes
Abstract
A method and apparatus for analyzing nucleic acids includes immobilizing nucleic probes at specific sites within a microchannel structure and moving target nucleic acids into proximity to the probes in order to allow hybridization and fluorescence detection of specific target sequences.
- Inventors:
-
- Knoxville, TN
- Oak Ridge, TN
- Issue Date:
- Research Org.:
- Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
- OSTI Identifier:
- 874367
- Patent Number(s):
- 6376181
- Assignee:
- UT-Battelle, LLC (Oak Ridge, TN)
- Patent Classifications (CPCs):
-
B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01J - CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY
B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- DOE Contract Number:
- AC05-84OR21400
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- method; analyzing; nucleic; acids; means; substrate; microchannel; structure; containing; immobilized; acid; probes; apparatus; immobilizing; specific; sites; moving; target; proximity; allow; hybridization; fluorescence; detection; sequences; nucleic acid; target nucleic; acid probe; channel structure; /435/436/
Citation Formats
Ramsey, J Michael, and Foote, Robert S. Method for analyzing nucleic acids by means of a substrate having a microchannel structure containing immobilized nucleic acid probes. United States: N. p., 2002.
Web.
Ramsey, J Michael, & Foote, Robert S. Method for analyzing nucleic acids by means of a substrate having a microchannel structure containing immobilized nucleic acid probes. United States.
Ramsey, J Michael, and Foote, Robert S. Tue .
"Method for analyzing nucleic acids by means of a substrate having a microchannel structure containing immobilized nucleic acid probes". United States. https://www.osti.gov/servlets/purl/874367.
@article{osti_874367,
title = {Method for analyzing nucleic acids by means of a substrate having a microchannel structure containing immobilized nucleic acid probes},
author = {Ramsey, J Michael and Foote, Robert S},
abstractNote = {A method and apparatus for analyzing nucleic acids includes immobilizing nucleic probes at specific sites within a microchannel structure and moving target nucleic acids into proximity to the probes in order to allow hybridization and fluorescence detection of specific target sequences.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2002},
month = {1}
}
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