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Title: Opto-acoustic recanilization delivery system

Abstract

Fiber delivered laser pulses emulsify thrombus by mechanical stresses that include a combination of pressure, tension and shear stress. Laser radiation is delivered to the locality of a thrombus and the radiation is absorbed by blood, blood dot, or other present materials. The combination of a leading pressure wave and subsequent vapor bubble cause efficient, emulsification of thrombus. Operating the laser in a low average power mode alleviates potential thermal complications. The laser is operated in a high repetition rate mode to take advantage of ultrasound frequency effects of thrombus dissolution as well as to decrease the total procedure time. Specific parameter ranges for operation are described. The device includes optical fibers surrounding a lumen intended for flow of a cooling agent. The fibers may be arranged concentrically around the lumen to deliver radiation and heat over as large an area as possible. An alternative design approach incorporates the optical fibers into the wall of the guiding catheter and utilizes the catheter lumen as the cooling channel. An eccentric tip enables rotation of the device to address all parts of the vasculature. The eccentricity can be provided via a variety of means: spring dip, balloon, protrusion, etc.

Inventors:
 [1];  [2];  [3];  [4];  [1];  [3];  [5]
  1. (Livermore, CA)
  2. (Danville, CA)
  3. (Berkeley, CA)
  4. (Orinda, CA)
  5. (San Francisco, CA)
Issue Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
OSTI Identifier:
874331
Patent Number(s):
6368318
Assignee:
The Regents of the University of California (Oakland, CA) LLNL
DOE Contract Number:  
W-7405-ENG-48
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
opto-acoustic; recanilization; delivery; fiber; delivered; laser; pulses; emulsify; thrombus; mechanical; stresses; combination; pressure; tension; shear; stress; radiation; locality; absorbed; blood; dot; materials; leading; wave; subsequent; vapor; bubble; efficient; emulsification; operating; average; power; mode; alleviates; potential; thermal; complications; operated; repetition; rate; advantage; ultrasound; frequency; effects; dissolution; decrease; total; procedure; time; specific; parameter; ranges; operation; described; device; optical; fibers; surrounding; lumen; intended; flow; cooling; agent; arranged; concentrically; deliver; heat; alternative; design; approach; incorporates; wall; guiding; catheter; utilizes; channel; eccentric; tip; enables; rotation; address; vasculature; eccentricity; provided; via; variety; means; spring; dip; balloon; protrusion; etc; optical fiber; laser pulse; laser radiation; repetition rate; pressure wave; mechanical stress; mechanical stresses; shear stress; /606/

Citation Formats

Visuri, Steven R., Da Silva, Luiz B., Celliers, Peter M., London, Richard A., Benett, William, Broughton, Kathryn, and Esch, Victor. Opto-acoustic recanilization delivery system. United States: N. p., 2002. Web.
Visuri, Steven R., Da Silva, Luiz B., Celliers, Peter M., London, Richard A., Benett, William, Broughton, Kathryn, & Esch, Victor. Opto-acoustic recanilization delivery system. United States.
Visuri, Steven R., Da Silva, Luiz B., Celliers, Peter M., London, Richard A., Benett, William, Broughton, Kathryn, and Esch, Victor. Tue . "Opto-acoustic recanilization delivery system". United States. https://www.osti.gov/servlets/purl/874331.
@article{osti_874331,
title = {Opto-acoustic recanilization delivery system},
author = {Visuri, Steven R. and Da Silva, Luiz B. and Celliers, Peter M. and London, Richard A. and Benett, William and Broughton, Kathryn and Esch, Victor},
abstractNote = {Fiber delivered laser pulses emulsify thrombus by mechanical stresses that include a combination of pressure, tension and shear stress. Laser radiation is delivered to the locality of a thrombus and the radiation is absorbed by blood, blood dot, or other present materials. The combination of a leading pressure wave and subsequent vapor bubble cause efficient, emulsification of thrombus. Operating the laser in a low average power mode alleviates potential thermal complications. The laser is operated in a high repetition rate mode to take advantage of ultrasound frequency effects of thrombus dissolution as well as to decrease the total procedure time. Specific parameter ranges for operation are described. The device includes optical fibers surrounding a lumen intended for flow of a cooling agent. The fibers may be arranged concentrically around the lumen to deliver radiation and heat over as large an area as possible. An alternative design approach incorporates the optical fibers into the wall of the guiding catheter and utilizes the catheter lumen as the cooling channel. An eccentric tip enables rotation of the device to address all parts of the vasculature. The eccentricity can be provided via a variety of means: spring dip, balloon, protrusion, etc.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2002},
month = {1}
}

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