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Title: Fluoralkenyl nortropanes

Abstract

Provided are compounds of the following formula: ##STR1## wherein R is C2-C6 mono- or multi-unsaturated hydrocarbon having one or more ethylene, acetylene or allene groups, A is 18 or 19, and X is H or halogen. The compounds of the invention bind to dopamine transporter with high affinity and selectivity and are thus useful as diagnostic and therapeutic agents for diseases associated with dopamine transporter dysfunction. The radiolabeled compounds are useful as imaging agents for visualizing the location and density of dopamine transporter by PET imaging.

Inventors:
 [1];  [2]
  1. Atlanta, GA
  2. Indianapolis, IN
Issue Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
OSTI Identifier:
874224
Patent Number(s):
6344179
Application Number:
09/553795
Assignee:
Emory University (Atlanta, GA)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07D - HETEROCYCLIC COMPOUNDS
DOE Contract Number:  
FG02-97ER62367
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
fluoralkenyl; nortropanes; provided; compounds; following; formula; str1; c2-c6; mono-; multi-unsaturated; hydrocarbon; ethylene; acetylene; allene; 18; 19; halogen; bind; dopamine; transporter; affinity; selectivity; useful; diagnostic; therapeutic; agents; diseases; associated; dysfunction; radiolabeled; imaging; visualizing; location; density; pet; pet imaging; saturated hydrocarbon; unsaturated hydrocarbon; /424/999/

Citation Formats

Goodman, Mark M, and Chen, Ping. Fluoralkenyl nortropanes. United States: N. p., 2002. Web.
Goodman, Mark M, & Chen, Ping. Fluoralkenyl nortropanes. United States.
Goodman, Mark M, and Chen, Ping. Tue . "Fluoralkenyl nortropanes". United States. https://www.osti.gov/servlets/purl/874224.
@article{osti_874224,
title = {Fluoralkenyl nortropanes},
author = {Goodman, Mark M and Chen, Ping},
abstractNote = {Provided are compounds of the following formula: ##STR1## wherein R is C2-C6 mono- or multi-unsaturated hydrocarbon having one or more ethylene, acetylene or allene groups, A is 18 or 19, and X is H or halogen. The compounds of the invention bind to dopamine transporter with high affinity and selectivity and are thus useful as diagnostic and therapeutic agents for diseases associated with dopamine transporter dysfunction. The radiolabeled compounds are useful as imaging agents for visualizing the location and density of dopamine transporter by PET imaging.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2002},
month = {1}
}

Patent:

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Works referenced in this record:

The Dopamine Transporter Is Absent in Parkinsonian Putamen and Reduced in the Caudate Nucleus
journal, January 1991


IPT: A novel iodinated ligand for the CNS dopamine transporter
journal, August 1995


Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter
journal, February 1996