Apparatus and method for collection and concentration of respirable particles into a small fluid volume

Simon, Jonathan N; Brown, Steve B

Title: Apparatus and method for collection and concentration of respirable particles into a small fluid volume

Abstract

An apparatus and method for the collection of respirable particles and concentration of such particles into a small fluid volume. The apparatus captures and concentrates small (1-10 .mu.m) respirable particles into a sub-millileter volume of fluid. The method involves a two step operation, collection and concentration: wherein collection of particles is by a wetted surface having small vertical slits that act as capillary channels; and concentration is carried out by transfer of the collected particles to a small volume (sub-milliliter) container by centrifugal force whereby the particles are forced through the vertical slits and contact a non-wetted wall surface, and are deflected to the bottom where they are contained for analysis, such as a portable flow cytometer or a portable PCR DNA analysis system.

Inventors:

Simon, Jonathan N ^[1]; Brown, Steve B ^[2]

San Leandro, CA
Livermore, CA

Issue Date:: 2002-01-01

Research Org.:: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)

OSTI Identifier:: 874197

Patent Number(s):: 6337213

Assignee:: The Regents of the University of California (Oakland, CA)

Patent Classifications (CPCs):: B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01D - SEPARATION

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

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B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01D - SEPARATION
B01D45/10 - which are wetted
B01D45/14 - generated by rotating vanes, discs, drums or brushes

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G01N1/2211 - {with cyclones}
G01N1/2273 - {Atmospheric sampling}
G01N1/4077 - {by other techniques involving separation of suspended solids}
G01N2001/245 - {Fans}

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
Y10T436/25375 - Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
Y10T436/255 - including use of a solid sorbent, semipermeable membrane, or liquid extraction
Y10T436/25875 - Gaseous sample or with change of physical state

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DOE Contract Number:: W-7405-ENG-48

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: apparatus; method; collection; concentration; respirable; particles; fluid; volume; captures; concentrates; 1-10; mum; sub-millileter; involves; step; operation; wetted; surface; vertical; slits; capillary; channels; carried; transfer; collected; sub-milliliter; container; centrifugal; force; forced; contact; non-wetted; wall; deflected; bottom; contained; analysis; portable; flow; cytometer; pcr; dna; centrifugal force; fluid volume; /436/55/422/

Citation Formats


                    Simon, Jonathan N, and Brown, Steve B. Apparatus and method for collection and concentration of respirable particles into a small fluid volume.  United States: N. p., 2002. 
        Web.

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                    Simon, Jonathan N, & Brown, Steve B. Apparatus and method for collection and concentration of respirable particles into a small fluid volume.  United States.

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                    Simon, Jonathan N, and Brown, Steve B. Tue .  
        "Apparatus and method for collection and concentration of respirable particles into a small fluid volume".  United States.  https://www.osti.gov/servlets/purl/874197.

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@article{osti_874197,

  title        = {Apparatus and method for collection and concentration of respirable particles into a small fluid volume},

  author       = {Simon, Jonathan N and Brown, Steve B},

  abstractNote = {An apparatus and method for the collection of respirable particles and concentration of such particles into a small fluid volume. The apparatus captures and concentrates small (1-10 .mu.m) respirable particles into a sub-millileter volume of fluid. The method involves a two step operation, collection and concentration: wherein collection of particles is by a wetted surface having small vertical slits that act as capillary channels; and concentration is carried out by transfer of the collected particles to a small volume (sub-milliliter) container by centrifugal force whereby the particles are forced through the vertical slits and contact a non-wetted wall surface, and are deflected to the bottom where they are contained for analysis, such as a portable flow cytometer or a portable PCR DNA analysis system.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2002},

  month        = {1}

}

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Works referenced in this record:

A Portable High-Throughput Liquid-Absorption Air Sampler for Respirable Aerosol Particles
journal, January 1998

Birenzvige, Amnon; Akiyemi, Agnes N.; Zaromb, Solomon
Aerosol Science and Technology, Vol. 29, Issue 2
https://doi.org/10.1080/02786829808965558

Detection and Estimation of Part-per-Billion Levels of Formaldehyde Using a Portable High-Throughput Liquid Absorption Air Sampler
journal, January 1998

Woo, Ching S.; Barry, Stuart E.; Zaromb, Solomon
Environmental Science & Technology, Vol. 32, Issue 1
https://doi.org/10.1021/es970465y

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Title: Apparatus and method for collection and concentration of respirable particles into a small fluid volume

Abstract

Citation Formats

A Portable High-Throughput Liquid-Absorption Air Sampler for Respirable Aerosol Particles journal, January 1998

Detection and Estimation of Part-per-Billion Levels of Formaldehyde Using a Portable High-Throughput Liquid Absorption Air Sampler journal, January 1998

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