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Title: Biochip scanner device

Abstract

A biochip scanner device used to detect and acquire fluorescence signal data from biological microchips or biochips and method of use are provided. The biochip scanner device includes a laser for emitting a laser beam. A modulator, such as an optical chopper modulates the laser beam. A scanning head receives the modulated laser beam and a scanning mechanics coupled to the scanning head moves the scanning head relative to the biochip. An optical fiber delivers the modulated laser beam to the scanning head. The scanning head collects the fluorescence light from the biochip, launches it into the same optical fiber, which delivers the fluorescence into a photodetector, such as a photodiode. The biochip scanner device is used in a row scanning method to scan selected rows of the biochip with the laser beam size matching the size of the immobilization site.

Inventors:
 [1];  [2];  [3]
  1. (Troitsk, RU)
  2. (Mayfield Heights, OH)
  3. (Darien, IL)
Issue Date:
Research Org.:
Argonne National Laboratory (ANL), Argonne, IL
OSTI Identifier:
874166
Patent Number(s):
6329661
Assignee:
The University of Chicago (Chicago, IL) ANL
DOE Contract Number:  
W-31109-ENG-38
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
biochip; scanner; device; detect; acquire; fluorescence; signal; data; biological; microchips; biochips; method; provided; laser; emitting; beam; modulator; optical; chopper; modulates; scanning; head; receives; modulated; mechanics; coupled; moves; fiber; delivers; collects; light; launches; photodetector; photodiode; row; scan; selected; rows; size; matching; immobilization; site; laser beam; optical fiber; /250/

Citation Formats

Perov, Alexander, Belgovskiy, Alexander I., and Mirzabekov, Andrei D. Biochip scanner device. United States: N. p., 2001. Web.
Perov, Alexander, Belgovskiy, Alexander I., & Mirzabekov, Andrei D. Biochip scanner device. United States.
Perov, Alexander, Belgovskiy, Alexander I., and Mirzabekov, Andrei D. Mon . "Biochip scanner device". United States. https://www.osti.gov/servlets/purl/874166.
@article{osti_874166,
title = {Biochip scanner device},
author = {Perov, Alexander and Belgovskiy, Alexander I. and Mirzabekov, Andrei D.},
abstractNote = {A biochip scanner device used to detect and acquire fluorescence signal data from biological microchips or biochips and method of use are provided. The biochip scanner device includes a laser for emitting a laser beam. A modulator, such as an optical chopper modulates the laser beam. A scanning head receives the modulated laser beam and a scanning mechanics coupled to the scanning head moves the scanning head relative to the biochip. An optical fiber delivers the modulated laser beam to the scanning head. The scanning head collects the fluorescence light from the biochip, launches it into the same optical fiber, which delivers the fluorescence into a photodetector, such as a photodiode. The biochip scanner device is used in a row scanning method to scan selected rows of the biochip with the laser beam size matching the size of the immobilization site.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2001},
month = {1}
}

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