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Title: Detection of biological molecules using chemical amplification and optical sensors

Abstract

Methods are provided for the determination of the concentration of biological levels of polyhydroxylated compounds, particularly glucose. The methods utilize an amplification system that is an analyte transducer immobilized in a polymeric matrix, where the system is implantable and biocompatible. Upon interrogation by an optical system, the amplification system produces a signal capable of detection external to the skin of the patient. Quantitation of the analyte of interest is achieved by measurement of the emitted signal. Specifically, the analyte transducer immobilized in a polymeric matrix can be a boronic acid moiety.

Inventors:
 [1];  [2]
  1. Valencia, CA
  2. Los Angeles, CA
Issue Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
OSTI Identifier:
874129
Patent Number(s):
6319540
Assignee:
MiniMed Inc. (Northridge, CA)
Patent Classifications (CPCs):
C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS
DOE Contract Number:  
W-7405-ENG-48
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
detection; biological; molecules; chemical; amplification; optical; sensors; methods; provided; determination; concentration; levels; polyhydroxylated; compounds; glucose; utilize; analyte; transducer; immobilized; polymeric; matrix; implantable; biocompatible; interrogation; produces; signal; capable; external; patient; quantitation; achieved; measurement; emitted; specifically; boronic; acid; moiety; optical sensor; biological molecules; methods utilize; /427/428/

Citation Formats

Van Antwerp, William Peter, and Mastrototaro, John Joseph. Detection of biological molecules using chemical amplification and optical sensors. United States: N. p., 2001. Web.
Van Antwerp, William Peter, & Mastrototaro, John Joseph. Detection of biological molecules using chemical amplification and optical sensors. United States.
Van Antwerp, William Peter, and Mastrototaro, John Joseph. Mon . "Detection of biological molecules using chemical amplification and optical sensors". United States. https://www.osti.gov/servlets/purl/874129.
@article{osti_874129,
title = {Detection of biological molecules using chemical amplification and optical sensors},
author = {Van Antwerp, William Peter and Mastrototaro, John Joseph},
abstractNote = {Methods are provided for the determination of the concentration of biological levels of polyhydroxylated compounds, particularly glucose. The methods utilize an amplification system that is an analyte transducer immobilized in a polymeric matrix, where the system is implantable and biocompatible. Upon interrogation by an optical system, the amplification system produces a signal capable of detection external to the skin of the patient. Quantitation of the analyte of interest is achieved by measurement of the emitted signal. Specifically, the analyte transducer immobilized in a polymeric matrix can be a boronic acid moiety.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2001},
month = {1}
}

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Works referenced in this record:

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