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Title: Nucleic acid-coupled colorimetric analyte detectors

Abstract

The present invention relates to methods and compositions for the direct detection of analytes and membrane conformational changes through the detection of color changes in biopolymeric materials. In particular, the present invention provide for the direct colorimetric detection of analytes using nucleic acid ligands at surfaces of polydiacetylene liposomes and related molecular layer systems.

Inventors:
 [1];  [2]
  1. Albany, CA
  2. Mainz, DE
Issue Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
OSTI Identifier:
874071
Patent Number(s):
6306598
Assignee:
Regents of the University of California (Oakland, CA)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
DOE Contract Number:  
AC03-76SF00098
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
nucleic; acid-coupled; colorimetric; analyte; detectors; relates; methods; compositions; direct; detection; analytes; membrane; conformational; changes; color; biopolymeric; materials; provide; acid; ligands; surfaces; polydiacetylene; liposomes; related; molecular; layer; systems; nucleic acid; polymeric material; color change; direct detection; analyte detector; /435/422/436/999/

Citation Formats

Charych, Deborah H, and Jonas, Ulrich. Nucleic acid-coupled colorimetric analyte detectors. United States: N. p., 2001. Web.
Charych, Deborah H, & Jonas, Ulrich. Nucleic acid-coupled colorimetric analyte detectors. United States.
Charych, Deborah H, and Jonas, Ulrich. Mon . "Nucleic acid-coupled colorimetric analyte detectors". United States. https://www.osti.gov/servlets/purl/874071.
@article{osti_874071,
title = {Nucleic acid-coupled colorimetric analyte detectors},
author = {Charych, Deborah H and Jonas, Ulrich},
abstractNote = {The present invention relates to methods and compositions for the direct detection of analytes and membrane conformational changes through the detection of color changes in biopolymeric materials. In particular, the present invention provide for the direct colorimetric detection of analytes using nucleic acid ligands at surfaces of polydiacetylene liposomes and related molecular layer systems.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2001},
month = {1}
}