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Title: Triggered optical biosensor

Abstract

An optical biosensor is provided for the detection of a multivalent target biomolecule, the biosensor including a substrate having a bilayer membrane thereon, a recognition molecule situated at the surface, the recognition molecule capable of binding with the multivalent target biomolecule, the recognition molecule further characterized as including a fluorescence label thereon and as being movable at the surface and a device for measuring a fluorescence change in response to binding between the recognition molecule and the multivalent target biomolecule.

Inventors:
 [1];  [1]
  1. Los Alamos, NM
Issue Date:
Research Org.:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
OSTI Identifier:
874029
Patent Number(s):
6297059
Application Number:
09/338457
Assignee:
Regents of University of California (Los Alamos, NM)
Patent Classifications (CPCs):
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y02 - TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE Y02A - TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
DOE Contract Number:  
W-7405-ENG-36
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
triggered; optical; biosensor; provided; detection; multivalent; target; biomolecule; including; substrate; bilayer; membrane; thereon; recognition; molecule; situated; surface; capable; binding; characterized; fluorescence; label; movable; device; measuring; change; response; bilayer membrane; optical biosensor; membrane thereon; /436/435/

Citation Formats

Song, Xuedong, and Swanson, Basil I. Triggered optical biosensor. United States: N. p., 2001. Web.
Song, Xuedong, & Swanson, Basil I. Triggered optical biosensor. United States.
Song, Xuedong, and Swanson, Basil I. Mon . "Triggered optical biosensor". United States. https://www.osti.gov/servlets/purl/874029.
@article{osti_874029,
title = {Triggered optical biosensor},
author = {Song, Xuedong and Swanson, Basil I},
abstractNote = {An optical biosensor is provided for the detection of a multivalent target biomolecule, the biosensor including a substrate having a bilayer membrane thereon, a recognition molecule situated at the surface, the recognition molecule capable of binding with the multivalent target biomolecule, the recognition molecule further characterized as including a fluorescence label thereon and as being movable at the surface and a device for measuring a fluorescence change in response to binding between the recognition molecule and the multivalent target biomolecule.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2001},
month = {1}
}

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Works referenced in this record:

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Biosynthetic lipid-tagging of antibodies
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Optical Signal Transduction Triggered by Protein−Ligand Binding:  Detection of Toxins Using Multivalent Binding
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Direct, Ultrasensitive, and Selective Optical Detection of Protein Toxins Using Multivalent Interactions
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Use of genetically engineered lipid-tagged antibody to generate functional europium chelate-loaded liposomes Application in fluoroimmunoassay
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