Stimulus sensitive gel with radioisotope and methods of making
Abstract
The present invention is a thermally reversible stimulus-sensitive gel or gelling copolymer radioisotope carrier that is a linear random copolymer of an [meth]acrylamide derivative and a hydrophilic comonomer, wherein the linear random copolymer is in the form of a plurality of linear chains having a plurality of molecular weights greater than or equal to a minimum gelling molecular weight cutoff. Addition of a biodegradable backbone and/or a therapeutic agent imparts further utility. The method of the present invention for making a thermally reversible stimulus-sensitive gelling copolymer radionuclcide carrier has the steps of: (a) mixing a stimulus-sensitive reversible gelling copolymer with an aqueous solvent as a stimulus-sensitive reversible gelling solution; and (b) mixing a radioisotope with said stimulus-sensitive reversible gelling solution as said radioisotope carrier. The gel is enhanced by either combining it with a biodegradable backbone and/or a therapeutic agent in a gelling solution made by mixing the copolymer with an aqueous solvent.
- Inventors:
-
- Selah, WA
- Kent, WA
- Richland, WA
- Kennewick, WA
- Issue Date:
- Research Org.:
- Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 874026
- Patent Number(s):
- 6296831
- Application Number:
- 09/058,712
- Assignee:
- Battelle Memorial Institute (Richland, WA)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- DOE Contract Number:
- AC06-76RL01830
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- stimulus; sensitive; radioisotope; methods; thermally; reversible; stimulus-sensitive; gelling; copolymer; carrier; linear; random; acrylamide; derivative; hydrophilic; comonomer; form; plurality; chains; molecular; weights; equal; minimum; weight; cutoff; addition; biodegradable; backbone; therapeutic; agent; imparts; utility; method; radionuclcide; steps; mixing; aqueous; solvent; solution; enhanced; combining; reversible gelling; random copolymer; aqueous solvent; molecular weight; molecular weights; therapeutic agent; thermally reversible; linear random; weight cu; acrylamide derivative; /424/
Citation Formats
Weller, Richard E, Lind, Michael A, Fisher, Darrell R, Gutowska, Anna, and Campbell, Allison A. Stimulus sensitive gel with radioisotope and methods of making. United States: N. p., 2001.
Web.
Weller, Richard E, Lind, Michael A, Fisher, Darrell R, Gutowska, Anna, & Campbell, Allison A. Stimulus sensitive gel with radioisotope and methods of making. United States.
Weller, Richard E, Lind, Michael A, Fisher, Darrell R, Gutowska, Anna, and Campbell, Allison A. Tue .
"Stimulus sensitive gel with radioisotope and methods of making". United States. https://www.osti.gov/servlets/purl/874026.
@article{osti_874026,
title = {Stimulus sensitive gel with radioisotope and methods of making},
author = {Weller, Richard E and Lind, Michael A and Fisher, Darrell R and Gutowska, Anna and Campbell, Allison A},
abstractNote = {The present invention is a thermally reversible stimulus-sensitive gel or gelling copolymer radioisotope carrier that is a linear random copolymer of an [meth]acrylamide derivative and a hydrophilic comonomer, wherein the linear random copolymer is in the form of a plurality of linear chains having a plurality of molecular weights greater than or equal to a minimum gelling molecular weight cutoff. Addition of a biodegradable backbone and/or a therapeutic agent imparts further utility. The method of the present invention for making a thermally reversible stimulus-sensitive gelling copolymer radionuclcide carrier has the steps of: (a) mixing a stimulus-sensitive reversible gelling copolymer with an aqueous solvent as a stimulus-sensitive reversible gelling solution; and (b) mixing a radioisotope with said stimulus-sensitive reversible gelling solution as said radioisotope carrier. The gel is enhanced by either combining it with a biodegradable backbone and/or a therapeutic agent in a gelling solution made by mixing the copolymer with an aqueous solvent.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Oct 02 00:00:00 EDT 2001},
month = {Tue Oct 02 00:00:00 EDT 2001}
}
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