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Title: Stimulus sensitive gel with radioisotope and methods of making

Abstract

The present invention is a thermally reversible stimulus-sensitive gel or gelling copolymer radioisotope carrier that is a linear random copolymer of an [meth]acrylamide derivative and a hydrophilic comonomer, wherein the linear random copolymer is in the form of a plurality of linear chains having a plurality of molecular weights greater than or equal to a minimum gelling molecular weight cutoff. Addition of a biodegradable backbone and/or a therapeutic agent imparts further utility. The method of the present invention for making a thermally reversible stimulus-sensitive gelling copolymer radionuclcide carrier has the steps of: (a) mixing a stimulus-sensitive reversible gelling copolymer with an aqueous solvent as a stimulus-sensitive reversible gelling solution; and (b) mixing a radioisotope with said stimulus-sensitive reversible gelling solution as said radioisotope carrier. The gel is enhanced by either combining it with a biodegradable backbone and/or a therapeutic agent in a gelling solution made by mixing the copolymer with an aqueous solvent.

Inventors:
 [1];  [2];  [3];  [3];  [4]
  1. Selah, WA
  2. Kent, WA
  3. Richland, WA
  4. Kennewick, WA
Issue Date:
Research Org.:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
874026
Patent Number(s):
6296831
Application Number:
09/058,712
Assignee:
Battelle Memorial Institute (Richland, WA)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
DOE Contract Number:  
AC06-76RL01830
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
stimulus; sensitive; radioisotope; methods; thermally; reversible; stimulus-sensitive; gelling; copolymer; carrier; linear; random; acrylamide; derivative; hydrophilic; comonomer; form; plurality; chains; molecular; weights; equal; minimum; weight; cutoff; addition; biodegradable; backbone; therapeutic; agent; imparts; utility; method; radionuclcide; steps; mixing; aqueous; solvent; solution; enhanced; combining; reversible gelling; random copolymer; aqueous solvent; molecular weight; molecular weights; therapeutic agent; thermally reversible; linear random; weight cu; acrylamide derivative; /424/

Citation Formats

Weller, Richard E, Lind, Michael A, Fisher, Darrell R, Gutowska, Anna, and Campbell, Allison A. Stimulus sensitive gel with radioisotope and methods of making. United States: N. p., 2001. Web.
Weller, Richard E, Lind, Michael A, Fisher, Darrell R, Gutowska, Anna, & Campbell, Allison A. Stimulus sensitive gel with radioisotope and methods of making. United States.
Weller, Richard E, Lind, Michael A, Fisher, Darrell R, Gutowska, Anna, and Campbell, Allison A. Tue . "Stimulus sensitive gel with radioisotope and methods of making". United States. https://www.osti.gov/servlets/purl/874026.
@article{osti_874026,
title = {Stimulus sensitive gel with radioisotope and methods of making},
author = {Weller, Richard E and Lind, Michael A and Fisher, Darrell R and Gutowska, Anna and Campbell, Allison A},
abstractNote = {The present invention is a thermally reversible stimulus-sensitive gel or gelling copolymer radioisotope carrier that is a linear random copolymer of an [meth]acrylamide derivative and a hydrophilic comonomer, wherein the linear random copolymer is in the form of a plurality of linear chains having a plurality of molecular weights greater than or equal to a minimum gelling molecular weight cutoff. Addition of a biodegradable backbone and/or a therapeutic agent imparts further utility. The method of the present invention for making a thermally reversible stimulus-sensitive gelling copolymer radionuclcide carrier has the steps of: (a) mixing a stimulus-sensitive reversible gelling copolymer with an aqueous solvent as a stimulus-sensitive reversible gelling solution; and (b) mixing a radioisotope with said stimulus-sensitive reversible gelling solution as said radioisotope carrier. The gel is enhanced by either combining it with a biodegradable backbone and/or a therapeutic agent in a gelling solution made by mixing the copolymer with an aqueous solvent.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2001},
month = {10}
}

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Works referenced in this record:

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