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Title: System and method for chromatography and electrophoresis using circular optical scanning

Abstract

A system and method is disclosed for chromatography and electrophoresis using circular optical scanning. One or more rectangular microchannel plates or radial microchannel plates has a set of analysis channels for insertion of molecular samples. One or more scanning devices repeatedly pass over the analysis channels in one direction at a predetermined rotational velocity and with a predetermined rotational radius. The rotational radius may be dynamically varied so as to monitor the molecular sample at various positions along a analysis channel. Sample loading robots may also be used to input molecular samples into the analysis channels. Radial microchannel plates are built from a substrate whose analysis channels are disposed at a non-parallel angle with respect to each other. A first step in the method accesses either a rectangular or radial microchannel plate, having a set of analysis channels, and second step passes a scanning device repeatedly in one direction over the analysis channels. As a third step, the scanning device is passed over the analysis channels at dynamically varying distances from a centerpoint of the scanning device. As a fourth step, molecular samples are loaded into the analysis channels with a robot.

Inventors:
 [1];  [2];  [1];  [3]
  1. Livermore, CA
  2. Oakland, CA
  3. Pleasanton, CA
Issue Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
OSTI Identifier:
874025
Patent Number(s):
6296749
Assignee:
Regents of University of California (Oakland, CA)
Patent Classifications (CPCs):
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
DOE Contract Number:  
W-7405-ENG-48
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
method; chromatography; electrophoresis; circular; optical; scanning; disclosed; rectangular; microchannel; plates; radial; set; analysis; channels; insertion; molecular; samples; devices; repeatedly; pass; direction; predetermined; rotational; velocity; radius; dynamically; varied; monitor; sample; various; positions; channel; loading; robots; input; built; substrate; disposed; non-parallel; angle; respect; step; accesses; plate; passes; device; third; passed; varying; distances; centerpoint; fourth; loaded; robot; channel plate; third step; microchannel plate; microchannel plates; optical scanning; circular optical; rotational velocity; scanning device; various positions; dynamically varied; /204/436/250/356/

Citation Formats

Balch, Joseph W, Brewer, Laurence R, Davidson, James C, and Kimbrough, Joseph R. System and method for chromatography and electrophoresis using circular optical scanning. United States: N. p., 2001. Web.
Balch, Joseph W, Brewer, Laurence R, Davidson, James C, & Kimbrough, Joseph R. System and method for chromatography and electrophoresis using circular optical scanning. United States.
Balch, Joseph W, Brewer, Laurence R, Davidson, James C, and Kimbrough, Joseph R. Mon . "System and method for chromatography and electrophoresis using circular optical scanning". United States. https://www.osti.gov/servlets/purl/874025.
@article{osti_874025,
title = {System and method for chromatography and electrophoresis using circular optical scanning},
author = {Balch, Joseph W and Brewer, Laurence R and Davidson, James C and Kimbrough, Joseph R},
abstractNote = {A system and method is disclosed for chromatography and electrophoresis using circular optical scanning. One or more rectangular microchannel plates or radial microchannel plates has a set of analysis channels for insertion of molecular samples. One or more scanning devices repeatedly pass over the analysis channels in one direction at a predetermined rotational velocity and with a predetermined rotational radius. The rotational radius may be dynamically varied so as to monitor the molecular sample at various positions along a analysis channel. Sample loading robots may also be used to input molecular samples into the analysis channels. Radial microchannel plates are built from a substrate whose analysis channels are disposed at a non-parallel angle with respect to each other. A first step in the method accesses either a rectangular or radial microchannel plate, having a set of analysis channels, and second step passes a scanning device repeatedly in one direction over the analysis channels. As a third step, the scanning device is passed over the analysis channels at dynamically varying distances from a centerpoint of the scanning device. As a fourth step, molecular samples are loaded into the analysis channels with a robot.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2001},
month = {1}
}