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Title: Sample injector for high pressure liquid chromatography

Abstract

Apparatus and method for driving a sample, having a well-defined volume, under pressure into a chromatography column. A conventional high pressure sampling valve is replaced by a sample injector composed of a pair of injector components connected in series to a common junction. The injector components are containers of porous dielectric material constructed so as to provide for electroosmotic flow of a sample into the junction. At an appropriate time, a pressure pulse from a high pressure source, that can be an electrokinetic pump, connected to the common junction, drives a portion of the sample, whose size is determined by the dead volume of the common junction, into the chromatographic column for subsequent separation and analysis. The apparatus can be fabricated on a substrate for microanalytical applications.

Inventors:
 [1];  [1];  [2]
  1. (Livermore, CA)
  2. (Castro Valley, CA)
Issue Date:
Research Org.:
SANDIA CORP
OSTI Identifier:
874001
Patent Number(s):
6290909
Assignee:
Sandia Corporation (Livermore, CA) SNL
DOE Contract Number:  
AC04-94AL85000
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
sample; injector; pressure; liquid; chromatography; apparatus; method; driving; well-defined; volume; column; conventional; sampling; valve; replaced; composed; pair; components; connected; series; common; junction; containers; porous; dielectric; material; constructed; provide; electroosmotic; flow; appropriate; time; pulse; source; electrokinetic; pump; drives; portion; size; determined; dead; chromatographic; subsequent; separation; analysis; fabricated; substrate; microanalytical; applications; subsequent separation; electrokinetic pump; liquid chromatograph; dead volume; liquid chromatography; dielectric material; chromatographic column; pressure liquid; chromatography column; appropriate time; pressure source; pressure pulse; sample injector; components connected; analytical applications; /422/73/204/210/

Citation Formats

Paul, Phillip H., Arnold, Don W., and Neyer, David W. Sample injector for high pressure liquid chromatography. United States: N. p., 2001. Web.
Paul, Phillip H., Arnold, Don W., & Neyer, David W. Sample injector for high pressure liquid chromatography. United States.
Paul, Phillip H., Arnold, Don W., and Neyer, David W. Mon . "Sample injector for high pressure liquid chromatography". United States. https://www.osti.gov/servlets/purl/874001.
@article{osti_874001,
title = {Sample injector for high pressure liquid chromatography},
author = {Paul, Phillip H. and Arnold, Don W. and Neyer, David W.},
abstractNote = {Apparatus and method for driving a sample, having a well-defined volume, under pressure into a chromatography column. A conventional high pressure sampling valve is replaced by a sample injector composed of a pair of injector components connected in series to a common junction. The injector components are containers of porous dielectric material constructed so as to provide for electroosmotic flow of a sample into the junction. At an appropriate time, a pressure pulse from a high pressure source, that can be an electrokinetic pump, connected to the common junction, drives a portion of the sample, whose size is determined by the dead volume of the common junction, into the chromatographic column for subsequent separation and analysis. The apparatus can be fabricated on a substrate for microanalytical applications.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2001},
month = {1}
}

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