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Title: Preparation of 2-hydroxy-5-oxoproline and analogs thereof

Abstract

The compound 2-hydroxy-5-oxoproline and analogs thereof may be used to produce an increase in carbon dioxide fixation, growth, dry weight, nutritional value (proteins and amino acids), nodulation and nitrogen fixation and photosynthetically derived chemical energy when applied to plants through their roots and/or through their foliar portions. The present invention includes an essentially quantitative chemical synthesis for this compound which is performed in a single step reaction of Fremy's Salt (potassium nitrosodisulphonate) with either glutamine or 2-pyrrolidone-5-carboxylic acid. Fremy's salt (potassium nitrosodisulphonate) is available commercially, or can be readily synthesized.

Inventors:
 [1];  [2]
  1. Santa Fe, NM
  2. Los Alamos, NM
Issue Date:
Research Org.:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
OSTI Identifier:
873985
Patent Number(s):
6288240
Assignee:
Regents of University of California (Los Alamos, NM)
Patent Classifications (CPCs):
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07D - HETEROCYCLIC COMPOUNDS
DOE Contract Number:  
W-7405-ENG-36
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
preparation; 2-hydroxy-5-oxoproline; analogs; compound; produce; increase; carbon; dioxide; fixation; growth; dry; weight; nutritional; value; proteins; amino; acids; nodulation; nitrogen; photosynthetically; derived; chemical; energy; applied; plants; roots; foliar; portions; essentially; quantitative; synthesis; performed; single; step; reaction; fremy; salt; potassium; nitrosodisulphonate; glutamine; 2-pyrrolidone-5-carboxylic; acid; available; commercially; readily; synthesized; chemical synthesis; dry weight; nitrogen fixation; single step; chemical energy; amino acid; carbon dioxide; carboxylic acid; amino acids; step reaction; /999/

Citation Formats

Martinez, Rodolfo A, and Unkefer, Pat J. Preparation of 2-hydroxy-5-oxoproline and analogs thereof. United States: N. p., 2001. Web.
Martinez, Rodolfo A, & Unkefer, Pat J. Preparation of 2-hydroxy-5-oxoproline and analogs thereof. United States.
Martinez, Rodolfo A, and Unkefer, Pat J. Mon . "Preparation of 2-hydroxy-5-oxoproline and analogs thereof". United States. https://www.osti.gov/servlets/purl/873985.
@article{osti_873985,
title = {Preparation of 2-hydroxy-5-oxoproline and analogs thereof},
author = {Martinez, Rodolfo A and Unkefer, Pat J},
abstractNote = {The compound 2-hydroxy-5-oxoproline and analogs thereof may be used to produce an increase in carbon dioxide fixation, growth, dry weight, nutritional value (proteins and amino acids), nodulation and nitrogen fixation and photosynthetically derived chemical energy when applied to plants through their roots and/or through their foliar portions. The present invention includes an essentially quantitative chemical synthesis for this compound which is performed in a single step reaction of Fremy's Salt (potassium nitrosodisulphonate) with either glutamine or 2-pyrrolidone-5-carboxylic acid. Fremy's salt (potassium nitrosodisulphonate) is available commercially, or can be readily synthesized.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2001},
month = {1}
}

Works referenced in this record:

The Glutamine Transaminase-ω-Amidase Pathwa
journal, January 1977


Oxidation of .alpha.-amino acids and .alpha.-hydroxy acids by Fremy's salt. A model for oxidases?
journal, October 1986


Action of Liver Glutamine Transaminase and l-Amino Acid Oxidase on Several Glutamine Analogs
journal, December 1973


Nitrosodisulphonates. Part I. Fremy's salt (potassium nitrosodisulphonate)
journal, January 1968


Occurrence of glutamine-2-oxoacid transaminase activity in the blue-green alga Anabaena cylindrica.
journal, January 1985