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Title: Utilization of nuclear structural proteins for targeted therapy and detection of proliferative and differentiation disorders

Abstract

The localization of nuclear apparatus proteins (NUMA) is used to identify tumor cells and different stages in the tumor progression and differentiation processes. There is a characteristic organization of NuMA in tumor cells and in phenotypically normal cells. NuMA distribution patterns are significantly less diffuse in proliferating non-malignant cells compared to malignant cells. The technique encompasses cell immunostaining using a NuMA specific antibody, and microscopic analysis of NuMA distribution within each nucleus.

Inventors:
 [1];  [1]
  1. (Berkeley, CA)
Issue Date:
Research Org.:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA
OSTI Identifier:
873984
Patent Number(s):
6287790
Assignee:
Regents of University of California (Oakland, CA) LBNL
DOE Contract Number:  
AC03-76SF00098
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
utilization; nuclear; structural; proteins; targeted; therapy; detection; proliferative; differentiation; disorders; localization; apparatus; numa; identify; tumor; cells; stages; progression; processes; characteristic; organization; phenotypically; normal; distribution; patterns; significantly; diffuse; proliferating; non-malignant; compared; malignant; technique; encompasses; cell; immunostaining; specific; antibody; microscopic; analysis; nucleus; normal cells; tumor cells; malignant cells; structural protein; /435/436/

Citation Formats

Lelievre, Sophie, and Bissell, Mina. Utilization of nuclear structural proteins for targeted therapy and detection of proliferative and differentiation disorders. United States: N. p., 2001. Web.
Lelievre, Sophie, & Bissell, Mina. Utilization of nuclear structural proteins for targeted therapy and detection of proliferative and differentiation disorders. United States.
Lelievre, Sophie, and Bissell, Mina. Mon . "Utilization of nuclear structural proteins for targeted therapy and detection of proliferative and differentiation disorders". United States. https://www.osti.gov/servlets/purl/873984.
@article{osti_873984,
title = {Utilization of nuclear structural proteins for targeted therapy and detection of proliferative and differentiation disorders},
author = {Lelievre, Sophie and Bissell, Mina},
abstractNote = {The localization of nuclear apparatus proteins (NUMA) is used to identify tumor cells and different stages in the tumor progression and differentiation processes. There is a characteristic organization of NuMA in tumor cells and in phenotypically normal cells. NuMA distribution patterns are significantly less diffuse in proliferating non-malignant cells compared to malignant cells. The technique encompasses cell immunostaining using a NuMA specific antibody, and microscopic analysis of NuMA distribution within each nucleus.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2001},
month = {1}
}

Patent:

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