Compositions for boron delivery to mammalian tissue
Abstract
Boron neutron capture therapy can utilize X.sub.y B.sub.20 H.sub.17 L where X is an alkali metal, y is 1 to 4, and L is a two electron donor such as NH.sub.3, and Na.sub.2 B.sub.10 H.sub.9 NCO, among others. These borane salts may be used free or encapsulated in liposomes. Liposomes may also have embedded within their bilayers carboranes to increase the amount of delivered .sup.10 B and/or to increase the tumor specificity of the liposome.
- Inventors:
-
- Encino, CA
- Los Angeles, CA
- Issue Date:
- Research Org.:
- Univ. of California (United States)
- OSTI Identifier:
- 873928
- Patent Number(s):
- 6274116
- Assignee:
- Reagents of University of California (Oakland, CA)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07F - ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- DOE Contract Number:
- FG03-95ER61975
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- compositions; boron; delivery; mammalian; tissue; neutron; capture; therapy; utilize; 20; 17; alkali; metal; electron; donor; nh; na; 10; nco; borane; salts; free; encapsulated; liposomes; embedded; bilayers; carboranes; increase; amount; delivered; tumor; specificity; liposome; alkali metal; neutron capture; boron neutron; capture therapy; electron donor; mammalian tissue; /424/
Citation Formats
Hawthorne, M Frederick, Feaks, Debra Arlene, and Shelly, Kenneth John. Compositions for boron delivery to mammalian tissue. United States: N. p., 2001.
Web.
Hawthorne, M Frederick, Feaks, Debra Arlene, & Shelly, Kenneth John. Compositions for boron delivery to mammalian tissue. United States.
Hawthorne, M Frederick, Feaks, Debra Arlene, and Shelly, Kenneth John. Mon .
"Compositions for boron delivery to mammalian tissue". United States. https://www.osti.gov/servlets/purl/873928.
@article{osti_873928,
title = {Compositions for boron delivery to mammalian tissue},
author = {Hawthorne, M Frederick and Feaks, Debra Arlene and Shelly, Kenneth John},
abstractNote = {Boron neutron capture therapy can utilize X.sub.y B.sub.20 H.sub.17 L where X is an alkali metal, y is 1 to 4, and L is a two electron donor such as NH.sub.3, and Na.sub.2 B.sub.10 H.sub.9 NCO, among others. These borane salts may be used free or encapsulated in liposomes. Liposomes may also have embedded within their bilayers carboranes to increase the amount of delivered .sup.10 B and/or to increase the tumor specificity of the liposome.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Mon Jan 01 00:00:00 EST 2001},
month = {Mon Jan 01 00:00:00 EST 2001}
}
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Works referenced in this record:
Model studies directed toward the boron neutron-capture therapy of cancer: boron delivery to murine tumors with liposomes.
journal, October 1992
- Shelly, K.; Feakes, D. A.; Hawthorne, M. F.
- Proceedings of the National Academy of Sciences, Vol. 89, Issue 19