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Title: Purine inhibitors of protein kinases, G proteins and polymerases

Abstract

The present invention relates to purine analogs that inhibit, inter alia, protein kinases, G-proteins and polymerases. In addition, the present invention relates to methods of using such purine analogs to inhibit protein kinases, G-proteins, polymerases and other cellular processes and to treat cellular proliferative diseases.

Inventors:
 [1];  [2];  [3];  [4]
  1. Berkeley, CA
  2. Oakland, CA
  3. Moraga, CA
  4. Roscoff, FR
Issue Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
OSTI Identifier:
873825
Patent Number(s):
6255485
Application Number:
09/130255
Assignee:
Regents of University of California (Oakland, CA); Centre National de la Recherche Scientifique (Paris, FR)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07D - HETEROCYCLIC COMPOUNDS
DOE Contract Number:  
AC03-76SF00098
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
purine; inhibitors; protein; kinases; proteins; polymerases; relates; analogs; inhibit; alia; g-proteins; addition; methods; cellular; processes; treat; proliferative; diseases; protein kinase; protein kinases; /999/

Citation Formats

Gray, Nathanael S, Schultz, Peter, Kim, Sung-Hou, and Meijer, Laurent. Purine inhibitors of protein kinases, G proteins and polymerases. United States: N. p., 2001. Web.
Gray, Nathanael S, Schultz, Peter, Kim, Sung-Hou, & Meijer, Laurent. Purine inhibitors of protein kinases, G proteins and polymerases. United States.
Gray, Nathanael S, Schultz, Peter, Kim, Sung-Hou, and Meijer, Laurent. Mon . "Purine inhibitors of protein kinases, G proteins and polymerases". United States. https://www.osti.gov/servlets/purl/873825.
@article{osti_873825,
title = {Purine inhibitors of protein kinases, G proteins and polymerases},
author = {Gray, Nathanael S and Schultz, Peter and Kim, Sung-Hou and Meijer, Laurent},
abstractNote = {The present invention relates to purine analogs that inhibit, inter alia, protein kinases, G-proteins and polymerases. In addition, the present invention relates to methods of using such purine analogs to inhibit protein kinases, G-proteins, polymerases and other cellular processes and to treat cellular proliferative diseases.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2001},
month = {1}
}

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Works referenced in this record:

Combinatorial synthesis of 2,9-substituted purines
journal, February 1997


Inhibition of Cyclin-Dependent Kinases by Purine Analogues
journal, September 1994


Cytokinin-Derived Cyclin-Dependent Kinase Inhibitors:  Synthesis and cdc2 Inhibitory Activity of Olomoucine and Related Compounds
journal, February 1997


A Structure-Based Library Approach to Kinase Inhibitors
journal, January 1996


Synthesis and activity of 2,6,9-trisubstituted purines
journal, November 1997


Inhibition of Cyclin-Dependent Kinases by Purine Analogues. Crystal Structure of Human cdk2 Complexed with Roscovitine
journal, January 1997