Composition for detection of cell density signal molecule
Abstract
Disclosed herein is a novel proteinaceous cell density signal molecule (CDS), which is secreted by fibroblastic cells in culture, preferably tendon cells, and which provides a means by which the cells self-regulate their proliferation and the expression of differentiated function. CDS, and the antibodies which recognize them, are important for the development of diagnostics and treatments for injuries and diseases involving connective tissues, particularly tendon. Also disclosed are methods of production and use.
- Inventors:
-
- Oakland, CA
- Issue Date:
- Research Org.:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- OSTI Identifier:
- 873781
- Patent Number(s):
- 6245899
- Assignee:
- Regents of University of California (Oakland, CA)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
- DOE Contract Number:
- AC03-76SF00098
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- composition; detection; cell; density; signal; molecule; disclosed; novel; proteinaceous; cds; secreted; fibroblastic; cells; culture; preferably; tendon; provides; means; self-regulate; proliferation; expression; differentiated; function; antibodies; recognize; diagnostics; treatments; injuries; diseases; involving; connective; tissues; particularly; methods; production; cell density; signal molecule; density signal; proteinaceous cell; novel proteinaceous; tendon cells; tendon cell; /530/
Citation Formats
Schwarz, Richard I. Composition for detection of cell density signal molecule. United States: N. p., 2001.
Web.
Schwarz, Richard I. Composition for detection of cell density signal molecule. United States.
Schwarz, Richard I. Mon .
"Composition for detection of cell density signal molecule". United States. https://www.osti.gov/servlets/purl/873781.
@article{osti_873781,
title = {Composition for detection of cell density signal molecule},
author = {Schwarz, Richard I},
abstractNote = {Disclosed herein is a novel proteinaceous cell density signal molecule (CDS), which is secreted by fibroblastic cells in culture, preferably tendon cells, and which provides a means by which the cells self-regulate their proliferation and the expression of differentiated function. CDS, and the antibodies which recognize them, are important for the development of diagnostics and treatments for injuries and diseases involving connective tissues, particularly tendon. Also disclosed are methods of production and use.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2001},
month = {1}
}
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Works referenced in this record:
A simple fractionation of chicken egg yolk yields a protein component that stimulates cell proliferation and differentiation in primary avian tendon cells
journal, May 1986
- Martis, Missie Joe; Schwarz, Richard I.
- In Vitro Cellular & Developmental Biology, Vol. 22, Issue 5