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Title: Microfluidic circuit designs for performing fluidic manipulations that reduce the number of pumping sources and fluid reservoirs

Abstract

A microfabricated device and method for proportioning and mixing biological or chemical materials by pressure- or vacuum-driven flow is disclosed. The microfabricated device mixes a plurality of materials in volumetric proportions controlled by the flow resistances of tributary reagent channels through which the materials are transported. The microchip includes two or more tributary reagent channels combining at one or more junctions to form one or more mixing channels. By varying the geometries of the channels (length, cross section, etc.), a plurality of reagent materials can be mixed at a junction such that the proportions of the reagent materials in the mixing channel depend on a ratio of the channel geometries and material properties. Such an approach facilitates flow division on the microchip without relying on techniques external to the microchip. Microchannel designs that provide the necessary flow division to accomplish valving operations using a minimum of pressure or vacuum sources are also described. In addition, microchannel designs that accomplish fluidic operation utilizing a minimal number of fluidic reservoirs are disclosed.

Inventors:
 [1];  [1]
  1. Knoxville, TN
Issue Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
873655
Patent Number(s):
6213151
Application Number:
09/557,435
Assignee:
UT-Battelle, LLC (Oak Ridge, TN) ORNL
DOE Contract Number:  
AC05-00OR22725
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
microfluidic; circuit; designs; performing; fluidic; manipulations; reduce; pumping; sources; fluid; reservoirs; microfabricated; device; method; proportioning; mixing; biological; chemical; materials; pressure-; vacuum-driven; flow; disclosed; mixes; plurality; volumetric; proportions; controlled; resistances; tributary; reagent; channels; transported; microchip; combining; junctions; form; varying; geometries; length; section; etc; mixed; junction; channel; depend; ratio; material; properties; approach; facilitates; division; relying; techniques; external; microchannel; provide; accomplish; valving; operations; minimum; pressure; vacuum; described; addition; operation; utilizing; minimal; microfabricated device; material properties; vacuum source; fluid reservoir; pumping source; chemical materials; chemical material; circuit designs; microfluidic circuit; flow resistance; fluid reservoirs; fluidic manipulations; channel design; /137/

Citation Formats

Jacobson, Stephen C, and Ramsey, J Michael. Microfluidic circuit designs for performing fluidic manipulations that reduce the number of pumping sources and fluid reservoirs. United States: N. p., 2001. Web.
Jacobson, Stephen C, & Ramsey, J Michael. Microfluidic circuit designs for performing fluidic manipulations that reduce the number of pumping sources and fluid reservoirs. United States.
Jacobson, Stephen C, and Ramsey, J Michael. Mon . "Microfluidic circuit designs for performing fluidic manipulations that reduce the number of pumping sources and fluid reservoirs". United States. https://www.osti.gov/servlets/purl/873655.
@article{osti_873655,
title = {Microfluidic circuit designs for performing fluidic manipulations that reduce the number of pumping sources and fluid reservoirs},
author = {Jacobson, Stephen C and Ramsey, J Michael},
abstractNote = {A microfabricated device and method for proportioning and mixing biological or chemical materials by pressure- or vacuum-driven flow is disclosed. The microfabricated device mixes a plurality of materials in volumetric proportions controlled by the flow resistances of tributary reagent channels through which the materials are transported. The microchip includes two or more tributary reagent channels combining at one or more junctions to form one or more mixing channels. By varying the geometries of the channels (length, cross section, etc.), a plurality of reagent materials can be mixed at a junction such that the proportions of the reagent materials in the mixing channel depend on a ratio of the channel geometries and material properties. Such an approach facilitates flow division on the microchip without relying on techniques external to the microchip. Microchannel designs that provide the necessary flow division to accomplish valving operations using a minimum of pressure or vacuum sources are also described. In addition, microchannel designs that accomplish fluidic operation utilizing a minimal number of fluidic reservoirs are disclosed.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2001},
month = {1}
}

Patent:

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