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Title: Birefringence imaging in biological tissue using polarization sensitive optical coherent tomography

Abstract

Employing a low coherence Michelson interferometer, two dimensional images of optical birefringence in turbid samples as a function of depth are measured. Polarization sensitive detection of the signal formed by interference of backscattered light from the sample and a mirror or reference plane in the reference arm which defines a reference optical path length, give the optical phase delay between light propagating along the fast and slow axes of the birefringence sample. Images showing the change in birefringence in response to irradiation of the sample are produced as an example of the detection apparatus and methodology. The technique allow rapid, noncontact investigation of tissue or sample diagnostic imaging for various medical or materials procedures.

Inventors:
 [1];  [2];  [3]
+ Show Inventor Affiliations
  1. Irvine, CA
  2. Austin, TX
  3. Laguna Niguel, CA
Issue Date:
Research Org.:
Univ. of California (United States)
OSTI Identifier:
873633
Patent Number(s):
6208415
Assignee:
Regents of University of California (Oakland, CA)
Patent Classifications (CPCs):
G - PHYSICS G01 - MEASURING G01B - MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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DOE Contract Number:  
FG03-91ER61227
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
birefringence; imaging; biological; tissue; polarization; sensitive; optical; coherent; tomography; employing; coherence; michelson; interferometer; dimensional; images; turbid; samples; function; depth; measured; detection; signal; formed; interference; backscattered; light; sample; mirror; reference; plane; arm; defines; path; length; phase; delay; propagating; fast; slow; axes; change; response; irradiation; produced; example; apparatus; methodology; technique; allow; rapid; noncontact; investigation; diagnostic; various; medical; materials; procedures; reference plane; optical phase; phase delay; sensitive detection; detection apparatus; path length; scattered light; optical path; biological tissue; allow rapid; polarization sensitive; sensitive optical; diagnostic imaging; michelson interferometer; dimensional image; dimensional images; /356/

Citation Formats

De Boer, Johannes F, Milner, Thomas E, and Nelson, J Stuart. Birefringence imaging in biological tissue using polarization sensitive optical coherent tomography. United States: N. p., 2001. Web.
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De Boer, Johannes F, Milner, Thomas E, & Nelson, J Stuart. Birefringence imaging in biological tissue using polarization sensitive optical coherent tomography. United States.
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De Boer, Johannes F, Milner, Thomas E, and Nelson, J Stuart. Mon . "Birefringence imaging in biological tissue using polarization sensitive optical coherent tomography". United States. https://www.osti.gov/servlets/purl/873633.
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@article{osti_873633,
title = {Birefringence imaging in biological tissue using polarization sensitive optical coherent tomography},
author = {De Boer, Johannes F and Milner, Thomas E and Nelson, J Stuart},
abstractNote = {Employing a low coherence Michelson interferometer, two dimensional images of optical birefringence in turbid samples as a function of depth are measured. Polarization sensitive detection of the signal formed by interference of backscattered light from the sample and a mirror or reference plane in the reference arm which defines a reference optical path length, give the optical phase delay between light propagating along the fast and slow axes of the birefringence sample. Images showing the change in birefringence in response to irradiation of the sample are produced as an example of the detection apparatus and methodology. The technique allow rapid, noncontact investigation of tissue or sample diagnostic imaging for various medical or materials procedures.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Mon Jan 01 00:00:00 EST 2001},
month = {Mon Jan 01 00:00:00 EST 2001}
}
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