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Title: Methods and computer executable instructions for rapidly calculating simulated particle transport through geometrically modeled treatment volumes having uniform volume elements for use in radiotherapy

Abstract

Methods and computer executable instructions are disclosed for ultimately developing a dosimetry plan for a treatment volume targeted for irradiation during cancer therapy. The dosimetry plan is available in "real-time" which especially enhances clinical use for in vivo applications. The real-time is achieved because of the novel geometric model constructed for the planned treatment volume which, in turn, allows for rapid calculations to be performed for simulated movements of particles along particle tracks there through. The particles are exemplary representations of neutrons emanating from a neutron source during BNCT. In a preferred embodiment, a medical image having a plurality of pixels of information representative of a treatment volume is obtained. The pixels are: (i) converted into a plurality of substantially uniform volume elements having substantially the same shape and volume of the pixels; and (ii) arranged into a geometric model of the treatment volume. An anatomical material associated with each uniform volume element is defined and stored. Thereafter, a movement of a particle along a particle track is defined through the geometric model along a primary direction of movement that begins in a starting element of the uniform volume elements and traverses to a next element of the uniform volumemore » elements. The particle movement along the particle track is effectuated in integer based increments along the primary direction of movement until a position of intersection occurs that represents a condition where the anatomical material of the next element is substantially different from the anatomical material of the starting element. This position of intersection is then useful for indicating whether a neutron has been captured, scattered or exited from the geometric model. From this intersection, a distribution of radiation doses can be computed for use in the cancer therapy. The foregoing represents an advance in computational times by multiple factors of time magnitudes.

Inventors:
 [1];  [2];  [3]
+ Show Inventor Affiliations
  1. Helena, MT
  2. Bozeman, MT
  3. Idaho Falls, ID
Issue Date:
Research Org.:
Idaho National Laboratory (INL), Idaho Falls, ID (United States)
OSTI Identifier:
873506
Patent Number(s):
6175761
Application Number:
09/063736
Assignee:
Bechtel BWXT Idaho, LLC (Idaho Falls, ID)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61N - ELECTROTHERAPY
Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10S - TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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DOE Contract Number:  
AC07-94ID13223
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
methods; computer; executable; instructions; rapidly; calculating; simulated; particle; transport; geometrically; modeled; treatment; volumes; uniform; volume; elements; radiotherapy; disclosed; ultimately; developing; dosimetry; plan; targeted; irradiation; cancer; therapy; available; real-time; especially; enhances; clinical; vivo; applications; achieved; novel; geometric; model; constructed; planned; allows; rapid; calculations; performed; movements; particles; tracks; exemplary; representations; neutrons; emanating; neutron; source; bnct; preferred; embodiment; medical; image; plurality; pixels; information; representative; obtained; converted; substantially; shape; ii; arranged; anatomical; material; associated; element; defined; stored; thereafter; movement; track; primary; direction; begins; starting; traverses; effectuated; integer; based; increments; position; intersection; occurs; represents; condition; useful; indicating; captured; scattered; exited; distribution; radiation; doses; computed; foregoing; advance; computational; times; multiple; factors; time; magnitudes; particle tracks; particle transport; preferred embodiment; substantially uniform; radiation dose; neutron source; cancer therapy; model constructed; computer executable; particle track; executable instructions; /600/128/378/

Citation Formats

Frandsen, Michael W, Wessol, Daniel E, and Wheeler, Floyd J. Methods and computer executable instructions for rapidly calculating simulated particle transport through geometrically modeled treatment volumes having uniform volume elements for use in radiotherapy. United States: N. p., 2001. Web.
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Frandsen, Michael W, Wessol, Daniel E, & Wheeler, Floyd J. Methods and computer executable instructions for rapidly calculating simulated particle transport through geometrically modeled treatment volumes having uniform volume elements for use in radiotherapy. United States.
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Frandsen, Michael W, Wessol, Daniel E, and Wheeler, Floyd J. Mon . "Methods and computer executable instructions for rapidly calculating simulated particle transport through geometrically modeled treatment volumes having uniform volume elements for use in radiotherapy". United States. https://www.osti.gov/servlets/purl/873506.
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@article{osti_873506,
title = {Methods and computer executable instructions for rapidly calculating simulated particle transport through geometrically modeled treatment volumes having uniform volume elements for use in radiotherapy},
author = {Frandsen, Michael W and Wessol, Daniel E and Wheeler, Floyd J},
abstractNote = {Methods and computer executable instructions are disclosed for ultimately developing a dosimetry plan for a treatment volume targeted for irradiation during cancer therapy. The dosimetry plan is available in "real-time" which especially enhances clinical use for in vivo applications. The real-time is achieved because of the novel geometric model constructed for the planned treatment volume which, in turn, allows for rapid calculations to be performed for simulated movements of particles along particle tracks there through. The particles are exemplary representations of neutrons emanating from a neutron source during BNCT. In a preferred embodiment, a medical image having a plurality of pixels of information representative of a treatment volume is obtained. The pixels are: (i) converted into a plurality of substantially uniform volume elements having substantially the same shape and volume of the pixels; and (ii) arranged into a geometric model of the treatment volume. An anatomical material associated with each uniform volume element is defined and stored. Thereafter, a movement of a particle along a particle track is defined through the geometric model along a primary direction of movement that begins in a starting element of the uniform volume elements and traverses to a next element of the uniform volume elements. The particle movement along the particle track is effectuated in integer based increments along the primary direction of movement until a position of intersection occurs that represents a condition where the anatomical material of the next element is substantially different from the anatomical material of the starting element. This position of intersection is then useful for indicating whether a neutron has been captured, scattered or exited from the geometric model. From this intersection, a distribution of radiation doses can be computed for use in the cancer therapy. The foregoing represents an advance in computational times by multiple factors of time magnitudes.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2001},
month = {1}
}
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Works referenced in this record:

Methods for radiation dose distribution analysis and treatment planning in boron neutron capture therapy
journal, March 1994

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