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Title: Nucleic acids encoding human trithorax protein

Abstract

In accordance with the present invention, there is provided an isolated peptide having the characteristics of human trithorax protein (as well as DNA encoding same, antisense DNA derived therefrom and antagonists therefor). The invention peptide is characterized by having a DNA binding domain comprising multiple zinc fingers and at least 40% amino acid identity with respect to the DNA binding domain of Drosophila trithorax protein and at least 70% conserved sequence with respect to the DNA binding domain of Drosophila trithorax protein, and wherein said peptide is encoded by a gene located at chromosome 11 of the human genome at q23. Also provided are methods for the treatment of subject(s) suffering from immunodeficiency, developmental abnormality, inherited disease, or cancer by administering to said subject a therapeutically effective amount of one of the above-described agents (i.e., peptide, antagonist therefor, DNA encoding said peptide or antisense DNA derived therefrom). Also provided is a method for the diagnosis, in a subject, of immunodeficiency, developmental abnormality, inherited disease, or cancer associated with disruption of chromosome 11 at q23.

Inventors:
 [1];  [2];  [3];  [4]
  1. (Encinitas, CA)
  2. (Marseilles, FR)
  3. (Del Mar, CA)
  4. (San Diego, CA)
Issue Date:
Research Org.:
Salk Institute for Biological Studies (San Diego, CA)
OSTI Identifier:
873498
Patent Number(s):
6175000
Assignee:
Salk Institute for Biological Studies (La Jolla, CA) OAK
DOE Contract Number:  
FG03-88ER60694
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
nucleic; acids; encoding; human; trithorax; protein; accordance; provided; isolated; peptide; characteristics; dna; antisense; derived; therefrom; antagonists; characterized; binding; domain; comprising; multiple; zinc; fingers; 40; amino; acid; identity; respect; drosophila; 70; conserved; sequence; encoded; located; chromosome; 11; genome; q23; methods; treatment; subject; suffering; immunodeficiency; developmental; abnormality; inherited; disease; cancer; administering; therapeutically; effective; amount; above-described; agents; antagonist; method; diagnosis; associated; disruption; acids encoding; binding domain; effective amount; amino acid; nucleic acid; nucleic acids; dna encoding; derived therefrom; isolated peptide; dna binding; trithorax protein; therapeutically effective; human trithorax; /999/435/

Citation Formats

Evans, Glen A., Djabali, Malek, Selleri, Licia, and Parry, Pauline. Nucleic acids encoding human trithorax protein. United States: N. p., 2001. Web.
Evans, Glen A., Djabali, Malek, Selleri, Licia, & Parry, Pauline. Nucleic acids encoding human trithorax protein. United States.
Evans, Glen A., Djabali, Malek, Selleri, Licia, and Parry, Pauline. Mon . "Nucleic acids encoding human trithorax protein". United States. https://www.osti.gov/servlets/purl/873498.
@article{osti_873498,
title = {Nucleic acids encoding human trithorax protein},
author = {Evans, Glen A. and Djabali, Malek and Selleri, Licia and Parry, Pauline},
abstractNote = {In accordance with the present invention, there is provided an isolated peptide having the characteristics of human trithorax protein (as well as DNA encoding same, antisense DNA derived therefrom and antagonists therefor). The invention peptide is characterized by having a DNA binding domain comprising multiple zinc fingers and at least 40% amino acid identity with respect to the DNA binding domain of Drosophila trithorax protein and at least 70% conserved sequence with respect to the DNA binding domain of Drosophila trithorax protein, and wherein said peptide is encoded by a gene located at chromosome 11 of the human genome at q23. Also provided are methods for the treatment of subject(s) suffering from immunodeficiency, developmental abnormality, inherited disease, or cancer by administering to said subject a therapeutically effective amount of one of the above-described agents (i.e., peptide, antagonist therefor, DNA encoding said peptide or antisense DNA derived therefrom). Also provided is a method for the diagnosis, in a subject, of immunodeficiency, developmental abnormality, inherited disease, or cancer associated with disruption of chromosome 11 at q23.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2001},
month = {1}
}

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