Pyrrolo isoquinolines
Abstract
Compounds of the formula: ##STR1## wherein X, Y, and R, independently of one another, is each a H; halogen, wherein said halogen is selected from the group consisting of .sup.123 I, .sup.124 I, .sup.125 I, .sup.131 I, .sup.75 Br, .sup.76 Br, .sup.77 Br, .sup.82 Br, .sup.18 F, or .sup.210 At; small alkyl, small alkenyl, or small alkynyl, any of which contains from one to about six carbon atoms and optionally having a carbon atom replaced by an O or S; or halogen substituted-small alkyl, halogen substituted-small alkenyl, or halogen substituted-small alkynyl wherein said compound contains at least one radioacitve halogen. The compounds bind to the serotonin transporter. Depending upon the choice of halogen substituent, the compounds are useful for PET or SPECT imaging, diagnosis and treatment of psychiatric disorders such as depression, anxiety, obsessive-compulsive disorder, and other conditions associated with defects of serotonin transporter function.
- Inventors:
-
- Atlanta, GA
- Cincinnati, OH
- Issue Date:
- Research Org.:
- Sandia National Laboratories (SNL), Albuquerque, NM, and Livermore, CA (United States)
- OSTI Identifier:
- 873450
- Patent Number(s):
- 6162417
- Assignee:
- Emory University (Atlanta, GA)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07D - HETEROCYCLIC COMPOUNDS
- DOE Contract Number:
- AC04-76
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- pyrrolo; isoquinolines; compounds; formula; str1; independently; halogen; selected; consisting; 123; 124; 125; 131; 75; br; 76; 77; 82; 18; 210; alkyl; alkenyl; alkynyl; contains; six; carbon; atoms; optionally; atom; replaced; substituted-small; compound; radioacitve; bind; serotonin; transporter; depending; choice; substituent; useful; pet; spect; imaging; diagnosis; treatment; psychiatric; disorders; depression; anxiety; obsessive-compulsive; disorder; conditions; associated; defects; function; serotonin transporter; carbon atoms; carbon atom; compound contains; /424/999/
Citation Formats
Goodman, Mark M, and Shi, Bing Z. Pyrrolo isoquinolines. United States: N. p., 2000.
Web.
Goodman, Mark M, & Shi, Bing Z. Pyrrolo isoquinolines. United States.
Goodman, Mark M, and Shi, Bing Z. Sat .
"Pyrrolo isoquinolines". United States. https://www.osti.gov/servlets/purl/873450.
@article{osti_873450,
title = {Pyrrolo isoquinolines},
author = {Goodman, Mark M and Shi, Bing Z},
abstractNote = {Compounds of the formula: ##STR1## wherein X, Y, and R, independently of one another, is each a H; halogen, wherein said halogen is selected from the group consisting of .sup.123 I, .sup.124 I, .sup.125 I, .sup.131 I, .sup.75 Br, .sup.76 Br, .sup.77 Br, .sup.82 Br, .sup.18 F, or .sup.210 At; small alkyl, small alkenyl, or small alkynyl, any of which contains from one to about six carbon atoms and optionally having a carbon atom replaced by an O or S; or halogen substituted-small alkyl, halogen substituted-small alkenyl, or halogen substituted-small alkynyl wherein said compound contains at least one radioacitve halogen. The compounds bind to the serotonin transporter. Depending upon the choice of halogen substituent, the compounds are useful for PET or SPECT imaging, diagnosis and treatment of psychiatric disorders such as depression, anxiety, obsessive-compulsive disorder, and other conditions associated with defects of serotonin transporter function.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2000},
month = {1}
}
Works referenced in this record:
Radiosynthesis and biodistribution of the S-[18F]fluoroethyl analog of McN5652
journal, May 1996
- Suehiro, Makiko; Greenberg, Joel H.; Shiue, Chyng-Yann
- Nuclear Medicine and Biology, Vol. 23, Issue 4