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Title: Method for sequential injection of liquid samples for radioisotope separations

Abstract

The present invention is a method of separating a short-lived daughter isotope from a longer lived parent isotope, with recovery of the parent isotope for further use. Using a system with a bi-directional pump and one or more valves, a solution of the parent isotope is processed to generate two separate solutions, one of which contains the daughter isotope, from which the parent has been removed with a high decontamination factor, and the other solution contains the recovered parent isotope. The process can be repeated on this solution of the parent isotope. The system with the fluid drive and one or more valves is controlled by a program on a microprocessor executing a series of steps to accomplish the operation. In one approach, the cow solution is passed through a separation medium that selectively retains the desired daughter isotope, while the parent isotope and the matrix pass through the medium. After washing this medium, the daughter is released from the separation medium using another solution. With the automated generator of the present invention, all solution handling steps necessary to perform a daughter/parent radionuclide separation, e.g. Bi-213 from Ac-225 "cow" solution, are performed in a consistent, enclosed, and remotely operated format.more » Operator exposure and spread of contamination are greatly minimized compared to the manual generator procedure described in U.S. patent application Ser. No. 08/789,973, now U.S. Pat. No. 5,749,042, herein incorporated by reference. Using 16 mCi of Ac-225 there was no detectable external contamination of the instrument components.« less

Inventors:
 [1];  [2];  [1]
  1. (Richland, WA)
  2. (West Richland, WA)
Issue Date:
Research Org.:
BATTELLE MEMORIAL INSTITUTE
OSTI Identifier:
873407
Patent Number(s):
6153154
Assignee:
Battelle Memorial Institute (Richland, WA) PNNL
DOE Contract Number:  
AC06-76RL01830
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
method; sequential; injection; liquid; samples; radioisotope; separations; separating; short-lived; daughter; isotope; lived; parent; recovery; bi-directional; pump; valves; solution; processed; generate; separate; solutions; contains; removed; decontamination; factor; recovered; process; repeated; fluid; drive; controlled; microprocessor; executing; series; steps; accomplish; operation; approach; cow; passed; separation; medium; selectively; retains; desired; matrix; pass; washing; released; automated; generator; handling; perform; radionuclide; bi-213; ac-225; performed; consistent; enclosed; remotely; operated; format; operator; exposure; spread; contamination; greatly; minimized; compared; manual; procedure; described; application; ser; 08; 789; 973; 749; 042; incorporated; reference; 16; mci; detectable; external; instrument; components; remotely operated; liquid sample; daughter isotope; liquid samples; decontamination factor; isotope separation; parent isotope; solution contains; application ser; fluid drive; bi-directional pump; /423/

Citation Formats

Egorov, Oleg B., Grate, Jay W., and Bray, Lane A. Method for sequential injection of liquid samples for radioisotope separations. United States: N. p., 2000. Web.
Egorov, Oleg B., Grate, Jay W., & Bray, Lane A. Method for sequential injection of liquid samples for radioisotope separations. United States.
Egorov, Oleg B., Grate, Jay W., and Bray, Lane A. Sat . "Method for sequential injection of liquid samples for radioisotope separations". United States. https://www.osti.gov/servlets/purl/873407.
@article{osti_873407,
title = {Method for sequential injection of liquid samples for radioisotope separations},
author = {Egorov, Oleg B. and Grate, Jay W. and Bray, Lane A.},
abstractNote = {The present invention is a method of separating a short-lived daughter isotope from a longer lived parent isotope, with recovery of the parent isotope for further use. Using a system with a bi-directional pump and one or more valves, a solution of the parent isotope is processed to generate two separate solutions, one of which contains the daughter isotope, from which the parent has been removed with a high decontamination factor, and the other solution contains the recovered parent isotope. The process can be repeated on this solution of the parent isotope. The system with the fluid drive and one or more valves is controlled by a program on a microprocessor executing a series of steps to accomplish the operation. In one approach, the cow solution is passed through a separation medium that selectively retains the desired daughter isotope, while the parent isotope and the matrix pass through the medium. After washing this medium, the daughter is released from the separation medium using another solution. With the automated generator of the present invention, all solution handling steps necessary to perform a daughter/parent radionuclide separation, e.g. Bi-213 from Ac-225 "cow" solution, are performed in a consistent, enclosed, and remotely operated format. Operator exposure and spread of contamination are greatly minimized compared to the manual generator procedure described in U.S. patent application Ser. No. 08/789,973, now U.S. Pat. No. 5,749,042, herein incorporated by reference. Using 16 mCi of Ac-225 there was no detectable external contamination of the instrument components.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2000},
month = {1}
}

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