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Title: Kit for providing a technetium medical radioimaging agent

Abstract

The present invention is directed toward a kit for microbial reduction of a technetium compound to form other compounds of value in medical imaging. The technetium compound is combined in a mixture with non-growing microbial cells which contain a technetium-reducing enzyme system, a stabilizing agent and an electron donor in a saline solution under anaerobic conditions. The mixture is substantially free of an inorganic technetium reducing agent and its reduction products. The resulting product is Tc of lower oxidation states, the form of which can be partially controlled by the stabilizing agent. It has been discovered that the microorganisms Shewanella alga, strain Bry and Shewanella putrifacians, strain CN-32 contain the necessary enzyme systems for technetium reduction and can form both mono nuclear and polynuclear reduced Tc species depending on the stabilizing agent.

Inventors:
 [1];  [2];  [1]
  1. (Richland, WA)
  2. (Greybull, WY)
Issue Date:
Research Org.:
BATTELLE MEMORIAL INSTITUTE
OSTI Identifier:
873391
Patent Number(s):
6150155
Assignee:
Battelle Memorial Institute (Richland, WA) PNNL
DOE Contract Number:  
AC06-76RL01830
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
kit; providing; technetium; medical; radioimaging; agent; directed; microbial; reduction; compound; form; compounds; value; imaging; combined; mixture; non-growing; cells; contain; technetium-reducing; enzyme; stabilizing; electron; donor; saline; solution; anaerobic; conditions; substantially; free; inorganic; reducing; products; resulting; product; tc; oxidation; partially; controlled; discovered; microorganisms; shewanella; alga; strain; bry; putrifacians; cn-32; systems; mono; nuclear; polynuclear; reduced; species; depending; saline solution; resulting product; substantially free; reducing agent; anaerobic conditions; electron donor; stabilizing agent; microbial reduction; medical imaging; imaging agent; technetium compound; microbial cell; aerobic conditions; /435/424/430/

Citation Formats

Wildung, Raymond E., Garland, Thomas R., and Li, Shu-Mei W. Kit for providing a technetium medical radioimaging agent. United States: N. p., 2000. Web.
Wildung, Raymond E., Garland, Thomas R., & Li, Shu-Mei W. Kit for providing a technetium medical radioimaging agent. United States.
Wildung, Raymond E., Garland, Thomas R., and Li, Shu-Mei W. Sat . "Kit for providing a technetium medical radioimaging agent". United States. https://www.osti.gov/servlets/purl/873391.
@article{osti_873391,
title = {Kit for providing a technetium medical radioimaging agent},
author = {Wildung, Raymond E. and Garland, Thomas R. and Li, Shu-Mei W.},
abstractNote = {The present invention is directed toward a kit for microbial reduction of a technetium compound to form other compounds of value in medical imaging. The technetium compound is combined in a mixture with non-growing microbial cells which contain a technetium-reducing enzyme system, a stabilizing agent and an electron donor in a saline solution under anaerobic conditions. The mixture is substantially free of an inorganic technetium reducing agent and its reduction products. The resulting product is Tc of lower oxidation states, the form of which can be partially controlled by the stabilizing agent. It has been discovered that the microorganisms Shewanella alga, strain Bry and Shewanella putrifacians, strain CN-32 contain the necessary enzyme systems for technetium reduction and can form both mono nuclear and polynuclear reduced Tc species depending on the stabilizing agent.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2000},
month = {1}
}

Patent:

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