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Title: Method for obtaining chromosome painting probes

Abstract

A method is provided for determining a clastogenic signature of a sample of chromosomes by quantifying a frequency of a first type of chromosome aberration present in the sample; quantifying a frequency of a second, different type of chromosome aberration present in the sample; and comparing the frequency of the first type of chromosome aberration to the frequency of the second type of chromosome aberration. A method is also provided for using that clastogenic signature to identify a clastogenic agent or dosage to which the cells were exposed.

Inventors:
 [1]
  1. (San Ramon, CA)
Issue Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
OSTI Identifier:
873314
Patent Number(s):
6132974
Assignee:
Regents of University of California (Oakland, CA) LLNL
DOE Contract Number:  
W-7405-ENG-48
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
method; obtaining; chromosome; painting; probes; provided; determining; clastogenic; signature; sample; chromosomes; quantifying; frequency; type; aberration; comparing; identify; agent; dosage; cells; exposed; clastogenic signature; chromosome aberration; clastogenic agent; chromosome painting; /435/436/999/

Citation Formats

Lucas, Joe N. Method for obtaining chromosome painting probes. United States: N. p., 2000. Web.
Lucas, Joe N. Method for obtaining chromosome painting probes. United States.
Lucas, Joe N. Sat . "Method for obtaining chromosome painting probes". United States. https://www.osti.gov/servlets/purl/873314.
@article{osti_873314,
title = {Method for obtaining chromosome painting probes},
author = {Lucas, Joe N.},
abstractNote = {A method is provided for determining a clastogenic signature of a sample of chromosomes by quantifying a frequency of a first type of chromosome aberration present in the sample; quantifying a frequency of a second, different type of chromosome aberration present in the sample; and comparing the frequency of the first type of chromosome aberration to the frequency of the second type of chromosome aberration. A method is also provided for using that clastogenic signature to identify a clastogenic agent or dosage to which the cells were exposed.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2000},
month = {1}
}

Patent:

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