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Title: Method of coating a substrate with a calcium phosphate compound

Abstract

The present invention is a method of coating a substrate with a calcium phosphate compound using plasma enhanced MOCVD. The substrate is a solid material that may be porous or non-porous, including but not limited to metal, ceramic, glass and combinations thereof. The coated substrate is preferably used as an implant, including but not limited to orthopaedic, dental and combinations thereof. Calcium phosphate compound includes but is not limited to tricalcium phosphate (TCP), hydroxyapatite (HA) and combinations thereof. TCP is preferred on a titanium implant when implant resorbability is desired. HA is preferred when the bone bonding of new bone tissue into the structure of the implant is desired. Either or both of TCP and/or HA coated implants may be placed into a solution with an agent selected from the group of protein, antibiotic, antimicrobial, growth factor and combinations thereof that can be adsorbed into the coating before implantation. Once implanted, the release of TCP will also release the agent to improve growth of new bone tissues and/or to prevent infection.

Inventors:
 [1];  [1]
  1. Kennewick, WA
Issue Date:
Research Org.:
Battelle Memorial Institute, Columbus, OH (United States)
OSTI Identifier:
873212
Patent Number(s):
6113993
Assignee:
Battelle Memorial Institute (Richland, WA)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61F - FILTERS IMPLANTABLE INTO BLOOD VESSELS
C - CHEMISTRY C23 - COATING METALLIC MATERIAL C23C - COATING METALLIC MATERIAL
DOE Contract Number:  
AC06-76RL01830
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
method; coating; substrate; calcium; phosphate; compound; plasma; enhanced; mocvd; solid; material; porous; non-porous; including; limited; metal; ceramic; glass; combinations; coated; preferably; implant; orthopaedic; dental; tricalcium; tcp; hydroxyapatite; preferred; titanium; resorbability; desired; bone; bonding; tissue; structure; implants; placed; solution; agent; selected; protein; antibiotic; antimicrobial; growth; factor; adsorbed; implantation; implanted; release; improve; tissues; prevent; infection; bone tissue; plasma enhanced; solid material; coated substrate; agent selected; calcium phosphate; phosphate compound; /427/

Citation Formats

Gao, Yufei, and Campbell, Allison A. Method of coating a substrate with a calcium phosphate compound. United States: N. p., 2000. Web.
Gao, Yufei, & Campbell, Allison A. Method of coating a substrate with a calcium phosphate compound. United States.
Gao, Yufei, and Campbell, Allison A. Sat . "Method of coating a substrate with a calcium phosphate compound". United States. https://www.osti.gov/servlets/purl/873212.
@article{osti_873212,
title = {Method of coating a substrate with a calcium phosphate compound},
author = {Gao, Yufei and Campbell, Allison A},
abstractNote = {The present invention is a method of coating a substrate with a calcium phosphate compound using plasma enhanced MOCVD. The substrate is a solid material that may be porous or non-porous, including but not limited to metal, ceramic, glass and combinations thereof. The coated substrate is preferably used as an implant, including but not limited to orthopaedic, dental and combinations thereof. Calcium phosphate compound includes but is not limited to tricalcium phosphate (TCP), hydroxyapatite (HA) and combinations thereof. TCP is preferred on a titanium implant when implant resorbability is desired. HA is preferred when the bone bonding of new bone tissue into the structure of the implant is desired. Either or both of TCP and/or HA coated implants may be placed into a solution with an agent selected from the group of protein, antibiotic, antimicrobial, growth factor and combinations thereof that can be adsorbed into the coating before implantation. Once implanted, the release of TCP will also release the agent to improve growth of new bone tissues and/or to prevent infection.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2000},
month = {1}
}

Works referenced in this record:

Surface and bulk study of calcium phosphate bioceramics obtained by Metal Organic Chemical Vapor Deposition
journal, August 1996


Ceramic Thin-Film Formation on Functionalized Interfaces Through Biomimetic Processing
journal, April 1994