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Title: Peptides and methods against diabetes

Abstract

This invention relates to methods of preventing or reducing the severity of diabetes. In one embodiment, the method involves administering to the individual a peptide having substantially the sequence of a on-conserved region sequence of a T cell receptor present on the surface of T cells mediating diabetes or a fragment thereof, wherein the peptide or fragment is capable of causing an effect on the immune system to regulate the T cells. In particular, the T cell receptor has the V.beta. regional V.beta.6 or V.beta.14. In another embodiment, the method involves gene therapy. The invention also relates to methods of diagnosing diabetes by determining the presence of diabetes predominant T cell receptors.

Inventors:
 [1];  [2]
  1. (Underhill Center, VT)
  2. (Hinesburg, VT)
Issue Date:
OSTI Identifier:
873211
Patent Number(s):
6113903
Assignee:
Immune Response Corporation (Carlsbad, CA) OSTI
DOE Contract Number:  
ER 60502
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
peptides; methods; diabetes; relates; preventing; reducing; severity; embodiment; method; involves; administering; individual; peptide; substantially; sequence; on-conserved; region; cell; receptor; surface; cells; mediating; fragment; capable; causing; effect; immune; regulate; particular; beta; regional; 14; therapy; diagnosing; determining; presence; predominant; receptors; method involves; method involve; /424/530/

Citation Formats

Albertini, Richard J., and Falta, Michael T. Peptides and methods against diabetes. United States: N. p., 2000. Web.
Albertini, Richard J., & Falta, Michael T. Peptides and methods against diabetes. United States.
Albertini, Richard J., and Falta, Michael T. Sat . "Peptides and methods against diabetes". United States. https://www.osti.gov/servlets/purl/873211.
@article{osti_873211,
title = {Peptides and methods against diabetes},
author = {Albertini, Richard J. and Falta, Michael T.},
abstractNote = {This invention relates to methods of preventing or reducing the severity of diabetes. In one embodiment, the method involves administering to the individual a peptide having substantially the sequence of a on-conserved region sequence of a T cell receptor present on the surface of T cells mediating diabetes or a fragment thereof, wherein the peptide or fragment is capable of causing an effect on the immune system to regulate the T cells. In particular, the T cell receptor has the V.beta. regional V.beta.6 or V.beta.14. In another embodiment, the method involves gene therapy. The invention also relates to methods of diagnosing diabetes by determining the presence of diabetes predominant T cell receptors.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2000},
month = {1}
}

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