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Title: Micromechanical calorimetric sensor

Abstract

A calorimeter sensor apparatus is developed utilizing microcantilevered spring elements for detecting thermal changes within a sample containing biomolecules which undergo chemical and biochemical reactions. The spring element includes a bimaterial layer of chemicals on a coated region on at least one surface of the microcantilever. The chemicals generate a differential thermal stress across the surface upon reaction of the chemicals with an analyte or biomolecules within the sample due to the heat of chemical reactions in the sample placed on the coated region. The thermal stress across the spring element surface creates mechanical bending of the microcantilever. The spring element has a low thermal mass to allow detection and measuring of heat transfers associated with chemical and biochemical reactions within a sample placed on or near the coated region. A second surface may have a different material, or the second surface and body of microcantilever may be of an inert composition. The differential thermal stress between the surfaces of the microcantilever create bending of the cantilever. Deflections of the cantilever are detected by a variety of detection techniques. The microcantilever may be approximately 1 to 200 .mu.m long, approximately 1 to 50 .mu.m wide, and approximately 0.3 to 3.0more » .mu.m thick. A sensitivity for detection of deflections is in the range of 0.01 nanometers. The microcantilever is extremely sensitive to thermal changes in samples as small as 30 microliters.« less

Inventors:
 [1];  [1]
  1. Knoxville, TN
Issue Date:
Research Org.:
LOCKHEED MARTIN ENERGY RES COR
OSTI Identifier:
873126
Patent Number(s):
6096559
Assignee:
Lockheed Martin Energy Research Corporation (Oak Ridge, TN)
DOE Contract Number:  
AC05-96OR22464
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
micromechanical; calorimetric; sensor; calorimeter; apparatus; developed; utilizing; microcantilevered; spring; elements; detecting; thermal; changes; sample; containing; biomolecules; undergo; chemical; biochemical; reactions; element; bimaterial; layer; chemicals; coated; region; surface; microcantilever; generate; differential; stress; reaction; analyte; due; heat; placed; creates; mechanical; bending; mass; allow; detection; measuring; transfers; associated; near; material; inert; composition; surfaces; create; cantilever; deflections; detected; variety; techniques; approximately; 200; 50; wide; thick; sensitivity; range; 01; nanometers; extremely; sensitive; samples; 30; microliters; material layer; detection techniques; extremely sensitive; differential thermal; spring element; sample containing; thermal stress; heat transfer; chemical reaction; sensor apparatus; chemical reactions; thermal mass; microcantilevered spring; thermal changes; biochemical reactions; detecting thermal; /436/422/

Citation Formats

Thundat, Thomas G, and Doktycz, Mitchel J. Micromechanical calorimetric sensor. United States: N. p., 2000. Web.
Thundat, Thomas G, & Doktycz, Mitchel J. Micromechanical calorimetric sensor. United States.
Thundat, Thomas G, and Doktycz, Mitchel J. Sat . "Micromechanical calorimetric sensor". United States. https://www.osti.gov/servlets/purl/873126.
@article{osti_873126,
title = {Micromechanical calorimetric sensor},
author = {Thundat, Thomas G and Doktycz, Mitchel J},
abstractNote = {A calorimeter sensor apparatus is developed utilizing microcantilevered spring elements for detecting thermal changes within a sample containing biomolecules which undergo chemical and biochemical reactions. The spring element includes a bimaterial layer of chemicals on a coated region on at least one surface of the microcantilever. The chemicals generate a differential thermal stress across the surface upon reaction of the chemicals with an analyte or biomolecules within the sample due to the heat of chemical reactions in the sample placed on the coated region. The thermal stress across the spring element surface creates mechanical bending of the microcantilever. The spring element has a low thermal mass to allow detection and measuring of heat transfers associated with chemical and biochemical reactions within a sample placed on or near the coated region. A second surface may have a different material, or the second surface and body of microcantilever may be of an inert composition. The differential thermal stress between the surfaces of the microcantilever create bending of the cantilever. Deflections of the cantilever are detected by a variety of detection techniques. The microcantilever may be approximately 1 to 200 .mu.m long, approximately 1 to 50 .mu.m wide, and approximately 0.3 to 3.0 .mu.m thick. A sensitivity for detection of deflections is in the range of 0.01 nanometers. The microcantilever is extremely sensitive to thermal changes in samples as small as 30 microliters.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2000},
month = {1}
}

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