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Title: Method of synthesizing enriched decaborane for use in generating boron neutron capture therapy pharmaceuticals

Abstract

A method is described for synthesizing decaborane wherein at least about 90% of the boron atoms in the decaborane are the .sup.10 B isotope, comprising the steps of: (a) reacting boric acid with a C.sub.1 to C.sub.10 alkanol to form a .sup.10 B-alkyl borate wherein at least about 90% of the boron atoms in the boric acid are the .sup.10 B isotope; (b) reducing the .sup.10 B-alkyl borate to form an alkali metal .sup.10 B-borohydride; (c) converting the alkali metal .sup.10 B-borohydride to a .sup.10 B-tetradecahydroundecaborate ion; and (d) converting the .sup.10 B-tetradecahydroundecaborate ion to .sup.10 B-decaborane. Methods of preparing tetradecahydroundecaborate ions and decaborane from alkali metal borohydrides are also described.

Inventors:
 [1];  [1];  [2]
  1. (Idaho Falls, ID)
  2. (Upland, CA)
Issue Date:
Research Org.:
Idaho National Engineering and Environmental Laboratory, Idaho Falls, ID
OSTI Identifier:
873082
Patent Number(s):
6086837
Assignee:
Bechtel BWXT Idaho, LLC (Idaho, ID) INEEL
DOE Contract Number:  
AC07-94ID13223
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
method; synthesizing; enriched; decaborane; generating; boron; neutron; capture; therapy; pharmaceuticals; described; 90; atoms; 10; isotope; comprising; steps; reacting; boric; acid; alkanol; form; b-alkyl; borate; reducing; alkali; metal; b-borohydride; converting; b-tetradecahydroundecaborate; b-decaborane; methods; preparing; tetradecahydroundecaborate; borohydrides; boric acid; alkali metal; neutron capture; boron neutron; capture therapy; /423/

Citation Formats

Cowan, Robert L., Ginosar, Daniel M., and Dunks, Gary B. Method of synthesizing enriched decaborane for use in generating boron neutron capture therapy pharmaceuticals. United States: N. p., 2000. Web.
Cowan, Robert L., Ginosar, Daniel M., & Dunks, Gary B. Method of synthesizing enriched decaborane for use in generating boron neutron capture therapy pharmaceuticals. United States.
Cowan, Robert L., Ginosar, Daniel M., and Dunks, Gary B. Sat . "Method of synthesizing enriched decaborane for use in generating boron neutron capture therapy pharmaceuticals". United States. https://www.osti.gov/servlets/purl/873082.
@article{osti_873082,
title = {Method of synthesizing enriched decaborane for use in generating boron neutron capture therapy pharmaceuticals},
author = {Cowan, Robert L. and Ginosar, Daniel M. and Dunks, Gary B.},
abstractNote = {A method is described for synthesizing decaborane wherein at least about 90% of the boron atoms in the decaborane are the .sup.10 B isotope, comprising the steps of: (a) reacting boric acid with a C.sub.1 to C.sub.10 alkanol to form a .sup.10 B-alkyl borate wherein at least about 90% of the boron atoms in the boric acid are the .sup.10 B isotope; (b) reducing the .sup.10 B-alkyl borate to form an alkali metal .sup.10 B-borohydride; (c) converting the alkali metal .sup.10 B-borohydride to a .sup.10 B-tetradecahydroundecaborate ion; and (d) converting the .sup.10 B-tetradecahydroundecaborate ion to .sup.10 B-decaborane. Methods of preparing tetradecahydroundecaborate ions and decaborane from alkali metal borohydrides are also described.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2000},
month = {1}
}

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