Method of synthesizing enriched decaborane for use in generating boron neutron capture therapy pharmaceuticals
Abstract
A method is described for synthesizing decaborane wherein at least about 90% of the boron atoms in the decaborane are the .sup.10 B isotope, comprising the steps of: (a) reacting boric acid with a C.sub.1 to C.sub.10 alkanol to form a .sup.10 B-alkyl borate wherein at least about 90% of the boron atoms in the boric acid are the .sup.10 B isotope; (b) reducing the .sup.10 B-alkyl borate to form an alkali metal .sup.10 B-borohydride; (c) converting the alkali metal .sup.10 B-borohydride to a .sup.10 B-tetradecahydroundecaborate ion; and (d) converting the .sup.10 B-tetradecahydroundecaborate ion to .sup.10 B-decaborane. Methods of preparing tetradecahydroundecaborate ions and decaborane from alkali metal borohydrides are also described.
- Inventors:
-
- Idaho Falls, ID
- Upland, CA
- Issue Date:
- Research Org.:
- Idaho National Laboratory (INL), Idaho Falls, ID (United States)
- OSTI Identifier:
- 873082
- Patent Number(s):
- 6086837
- Assignee:
- Bechtel BWXT Idaho, LLC (Idaho, ID)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C01 - INORGANIC CHEMISTRY C01B - NON-METALLIC ELEMENTS
- DOE Contract Number:
- AC07-94ID13223
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- method; synthesizing; enriched; decaborane; generating; boron; neutron; capture; therapy; pharmaceuticals; described; 90; atoms; 10; isotope; comprising; steps; reacting; boric; acid; alkanol; form; b-alkyl; borate; reducing; alkali; metal; b-borohydride; converting; b-tetradecahydroundecaborate; b-decaborane; methods; preparing; tetradecahydroundecaborate; borohydrides; boric acid; alkali metal; neutron capture; boron neutron; capture therapy; /423/
Citation Formats
Cowan, Robert L, Ginosar, Daniel M, and Dunks, Gary B. Method of synthesizing enriched decaborane for use in generating boron neutron capture therapy pharmaceuticals. United States: N. p., 2000.
Web.
Cowan, Robert L, Ginosar, Daniel M, & Dunks, Gary B. Method of synthesizing enriched decaborane for use in generating boron neutron capture therapy pharmaceuticals. United States.
Cowan, Robert L, Ginosar, Daniel M, and Dunks, Gary B. Sat .
"Method of synthesizing enriched decaborane for use in generating boron neutron capture therapy pharmaceuticals". United States. https://www.osti.gov/servlets/purl/873082.
@article{osti_873082,
title = {Method of synthesizing enriched decaborane for use in generating boron neutron capture therapy pharmaceuticals},
author = {Cowan, Robert L and Ginosar, Daniel M and Dunks, Gary B},
abstractNote = {A method is described for synthesizing decaborane wherein at least about 90% of the boron atoms in the decaborane are the .sup.10 B isotope, comprising the steps of: (a) reacting boric acid with a C.sub.1 to C.sub.10 alkanol to form a .sup.10 B-alkyl borate wherein at least about 90% of the boron atoms in the boric acid are the .sup.10 B isotope; (b) reducing the .sup.10 B-alkyl borate to form an alkali metal .sup.10 B-borohydride; (c) converting the alkali metal .sup.10 B-borohydride to a .sup.10 B-tetradecahydroundecaborate ion; and (d) converting the .sup.10 B-tetradecahydroundecaborate ion to .sup.10 B-decaborane. Methods of preparing tetradecahydroundecaborate ions and decaborane from alkali metal borohydrides are also described.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Sat Jan 01 00:00:00 EST 2000},
month = {Sat Jan 01 00:00:00 EST 2000}
}
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Works referenced in this record:
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