Method for high specific bioproductivity of .alpha.,.omega.-alkanedicarboxylic acids
Abstract
This invention provides a low-cost method of producing .alpha.,.omega.-alkanedicarboxylic acids. Particular bioconversion conditions result in highly efficient conversion of fatty acid, fatty acid ester, or alkane substrates to diacids. Candida tropicalis AR40 or similar yeast strains are grown in a medium containing a carbon source and a nitrogen source at a temperature of 31.degree. C. to 38.degree. C., while additional carbon source is continuously added, until maximum cell growth is attained. Within 0-3 hours of this point, substrate is added to the culture to initiate conversion. An .alpha.,.omega.-alkanedicarboxylic acid made according to this method is also provided.
- Inventors:
-
- Schenectady, NY
- Rocky Hill, CT
- Issue Date:
- Research Org.:
- GE CORPORATE R & D
- OSTI Identifier:
- 873009
- Patent Number(s):
- 6066480
- Assignee:
- General Electric Company (Schenectady, NY)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {
- DOE Contract Number:
- FC36-95GO10099
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- method; specific; bioproductivity; alpha; omega; -alkanedicarboxylic; acids; provides; low-cost; producing; particular; bioconversion; conditions; result; highly; efficient; conversion; fatty; acid; ester; alkane; substrates; diacids; candida; tropicalis; ar40; similar; yeast; strains; grown; medium; containing; carbon; source; nitrogen; temperature; 31; degree; 38; additional; continuously; added; maximum; cell; growth; attained; 0-3; hours; substrate; culture; initiate; according; provided; acid ester; cell growth; highly efficient; carbon source; fatty acid; carboxylic acids; carboxylic acid; medium containing; nitrogen source; efficient conversion; dicarboxylic acid; -alkanedicarboxylic acid; -alkanedicarboxylic acids; dicarboxylic acids; /435/
Citation Formats
Mobley, David Paul, and Shank, Gary Keith. Method for high specific bioproductivity of .alpha.,.omega.-alkanedicarboxylic acids. United States: N. p., 2000.
Web.
Mobley, David Paul, & Shank, Gary Keith. Method for high specific bioproductivity of .alpha.,.omega.-alkanedicarboxylic acids. United States.
Mobley, David Paul, and Shank, Gary Keith. Sat .
"Method for high specific bioproductivity of .alpha.,.omega.-alkanedicarboxylic acids". United States. https://www.osti.gov/servlets/purl/873009.
@article{osti_873009,
title = {Method for high specific bioproductivity of .alpha.,.omega.-alkanedicarboxylic acids},
author = {Mobley, David Paul and Shank, Gary Keith},
abstractNote = {This invention provides a low-cost method of producing .alpha.,.omega.-alkanedicarboxylic acids. Particular bioconversion conditions result in highly efficient conversion of fatty acid, fatty acid ester, or alkane substrates to diacids. Candida tropicalis AR40 or similar yeast strains are grown in a medium containing a carbon source and a nitrogen source at a temperature of 31.degree. C. to 38.degree. C., while additional carbon source is continuously added, until maximum cell growth is attained. Within 0-3 hours of this point, substrate is added to the culture to initiate conversion. An .alpha.,.omega.-alkanedicarboxylic acid made according to this method is also provided.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2000},
month = {1}
}
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Works referenced in this record:
Antifungal properties of α,ω-alkanedicarboxylic acids and their dimethyl esters
journal, August 1976
- Gershon, Herman; Shanks, Larry
- Canadian Journal of Microbiology, Vol. 22, Issue 8
Microbial Production of Long-chain Dicarboxylic Acids from n -Alkanes: Part I. Screening and Properties of Microorganisms Producing Dicarboxylic Acids
journal, January 1971
- Shiio, Isamu; Uchio, Ryosuke
- Agricultural and Biological Chemistry, Vol. 35, Issue 13