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Title: Method for detecting and diagnosing disease caused by pathological protein aggregation

Abstract

A method is provided for detecting pathological macromolecules in a patient, comprising obtaining body fluid from the patient, pretreating the body fluid, subjecting the pretreated body fluid to size-exclusion chromatography to create an excluded fluid, and analyzing the excluded fluid to detect macromolecules having a predetermined molecular weight. The method also allows for comparing elution spectra with reference spectra of suspect pathologic proteins.

Inventors:
 [1];  [2];  [3]
  1. Naperville, IL
  2. Riverside, IL
  3. Knoxville, TN
Issue Date:
Research Org.:
Argonne National Laboratory (ANL), Argonne, IL
OSTI Identifier:
872999
Patent Number(s):
6063636
Assignee:
United States of America as represented by United States (Washington, DC); University of Tennessee (Knoxville, TN)
DOE Contract Number:  
W-31109-ENG-38
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
method; detecting; diagnosing; disease; caused; pathological; protein; aggregation; provided; macromolecules; patient; comprising; obtaining; fluid; pretreating; subjecting; pretreated; size-exclusion; chromatography; create; excluded; analyzing; detect; predetermined; molecular; weight; allows; comparing; elution; spectra; reference; suspect; pathologic; proteins; molecular weight; size-exclusion chromatography; disease caused; /436/530/

Citation Formats

Stevens, Fred J, Myatt, Elizabeth A, and Solomon, Alan. Method for detecting and diagnosing disease caused by pathological protein aggregation. United States: N. p., 2000. Web.
Stevens, Fred J, Myatt, Elizabeth A, & Solomon, Alan. Method for detecting and diagnosing disease caused by pathological protein aggregation. United States.
Stevens, Fred J, Myatt, Elizabeth A, and Solomon, Alan. Sat . "Method for detecting and diagnosing disease caused by pathological protein aggregation". United States. https://www.osti.gov/servlets/purl/872999.
@article{osti_872999,
title = {Method for detecting and diagnosing disease caused by pathological protein aggregation},
author = {Stevens, Fred J and Myatt, Elizabeth A and Solomon, Alan},
abstractNote = {A method is provided for detecting pathological macromolecules in a patient, comprising obtaining body fluid from the patient, pretreating the body fluid, subjecting the pretreated body fluid to size-exclusion chromatography to create an excluded fluid, and analyzing the excluded fluid to detect macromolecules having a predetermined molecular weight. The method also allows for comparing elution spectra with reference spectra of suspect pathologic proteins.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2000},
month = {1}
}

Patent:

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