Microfabricated therapeutic actuators and release mechanisms therefor

Lee, Abraham P; Fitch, Joseph P; Schumann, Daniel L; Da Silva, Luiz; Benett, William J; Krulevitch, Peter A

Title: Microfabricated therapeutic actuators and release mechanisms therefor

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Abstract

Microfabricated therapeutic actuators are fabricated using a shape memory polymer (SMP), a polyurethane-based material that undergoes a phase transformation at a specified temperature (Tg). At a temperature above temperature Tg material is soft and can be easily reshaped into another configuration. As the temperature is lowered below temperature Tg the new shape is fixed and locked in as long as the material stays below temperature Tg. Upon reheating the material to a temperature above Tg, the material will return to its original shape. By the use of such SMP material, SMP microtubing can be used as a retaining/release actuator for the delivery of material, such as embolic coils, for example, through catheters into aneurysms, for example. The microtubing can be manufactured in various sizes and the phase change temperature Tg is determinate for an intended temperature target and intended use. The SMP microtubing can be positioned around or within an end of a deposit material. Various heating arrangements can be utilized with the SMP release mechanism, and the SMP microtubing can include a metallic coating for enhanced light absorption.

Inventors:

Lee, Abraham P ^[1]; Fitch, Joseph P ^[2]; Schumann, Daniel L ^[3]; Da Silva, Luiz ^[4]; Benett, William J ^[2]; Krulevitch, Peter A ^[5]

Walnut Creek, CA
Livermore, CA
Concord, CA
Danville, CA
Pleasanton, CA

Issue Date:: 2000-01-01

Research Org.:: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)

OSTI Identifier:: 872987

Patent Number(s):: 6059815

Assignee:: Regents of University of California (Oakland, CA)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS
A61B17/12022 - {Occluding by internal devices, e.g. balloons or releasable wires
A61B17/1214 - {Coils or wires}
A61B2017/00867 - {shape memory effect
A61B2017/00871 - {polymeric}
A61B2017/12068 - {detachable by heat}
A61B2017/12077 - {Joint changing shape upon application of heat, e.g. bi-metal or reversible thermal memory}

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DOE Contract Number:: W-7405-ENG-48

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: microfabricated; therapeutic; actuators; release; mechanisms; fabricated; shape; memory; polymer; smp; polyurethane-based; material; undergoes; phase; transformation; specified; temperature; tg; soft; easily; reshaped; configuration; lowered; below; fixed; locked; stays; reheating; return; original; microtubing; retaining; actuator; delivery; embolic; coils; example; catheters; aneurysms; manufactured; various; sizes; change; determinate; intended; target; positioned; deposit; heating; arrangements; utilized; mechanism; metallic; coating; enhanced; light; absorption; release mechanism; various sizes; below temperature; phase transformation; original shape; microfabricated therapeutic; metallic coating; deposit material; smp microtubing; therapeutic actuators; temperature tg; phase change; shape memory; specified temperature; memory polymer; light absorption; release actuator; tg material; temperature target; stays below; polyurethane-based material; change temperature; smp material; enhanced light; embolic coils; embolic coil; lowered below; material stays; easily reshaped; intended temperature; therapeutic actuator; /606/

Citation Formats


                    Lee, Abraham P, Fitch, Joseph P, Schumann, Daniel L, Da Silva, Luiz, Benett, William J, and Krulevitch, Peter A. Microfabricated therapeutic actuators and release mechanisms therefor.  United States: N. p., 2000. 
        Web.

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                    Lee, Abraham P, Fitch, Joseph P, Schumann, Daniel L, Da Silva, Luiz, Benett, William J, & Krulevitch, Peter A. Microfabricated therapeutic actuators and release mechanisms therefor.  United States.

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                    Lee, Abraham P, Fitch, Joseph P, Schumann, Daniel L, Da Silva, Luiz, Benett, William J, and Krulevitch, Peter A. Sat .  
        "Microfabricated therapeutic actuators and release mechanisms therefor".  United States.  https://www.osti.gov/servlets/purl/872987.

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@article{osti_872987,

  title        = {Microfabricated therapeutic actuators and release mechanisms therefor},

  author       = {Lee, Abraham P and Fitch, Joseph P and Schumann, Daniel L and Da Silva, Luiz and Benett, William J and Krulevitch, Peter A},

  abstractNote = {Microfabricated therapeutic actuators are fabricated using a shape memory polymer (SMP), a polyurethane-based material that undergoes a phase transformation at a specified temperature (Tg). At a temperature above temperature Tg material is soft and can be easily reshaped into another configuration. As the temperature is lowered below temperature Tg the new shape is fixed and locked in as long as the material stays below temperature Tg. Upon reheating the material to a temperature above Tg, the material will return to its original shape. By the use of such SMP material, SMP microtubing can be used as a retaining/release actuator for the delivery of material, such as embolic coils, for example, through catheters into aneurysms, for example. The microtubing can be manufactured in various sizes and the phase change temperature Tg is determinate for an intended temperature target and intended use. The SMP microtubing can be positioned around or within an end of a deposit material. Various heating arrangements can be utilized with the SMP release mechanism, and the SMP microtubing can include a metallic coating for enhanced light absorption.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2000},

  month        = {1}

}

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