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Title: Method for determining surface properties of microparticles

Abstract

Second harmonic generation (SHG), sum frequency generation (SFG) and difference frequency generation (DFG) can be used for surface analysis or characterization of microparticles having a non-metallic surface feature. The microparticles can be centrosymmetric or such that non-metallic molecules of interest are centrosymmetrically distributed inside and outside the microparticles but not at the surface of the microparticles where the asymmetry aligns the molecules. The signal is quadratic in incident laser intensity or proportional to the product of two incident laser intensities for SFG, it is sharply peaked at the second harmonic wavelength, quadratic in the density of molecules adsorbed onto the microparticle surface, and linear in microparticles density. In medical or pharmacological applications, molecules of interest may be of drugs or toxins, for example.

Inventors:
 [1]
  1. (Ridgewood, NJ)
Issue Date:
Research Org.:
Columbia University
OSTI Identifier:
872968
Patent Number(s):
6055051
Assignee:
Trustees of Columbia University in City of New York (New York, NY) CHO
DOE Contract Number:  
FG02-91ER14226
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
method; determining; surface; properties; microparticles; harmonic; generation; shg; frequency; sfg; difference; dfg; analysis; characterization; non-metallic; feature; centrosymmetric; molecules; centrosymmetrically; distributed; inside; outside; asymmetry; aligns; signal; quadratic; incident; laser; intensity; proportional; product; intensities; sharply; peaked; wavelength; density; adsorbed; microparticle; linear; medical; pharmacological; applications; drugs; toxins; example; surface feature; incident laser; surface properties; difference frequency; surface analysis; laser intensities; frequency generation; harmonic generation; particle surface; metallic surface; determining surface; /356/

Citation Formats

Eisenthal, Kenneth B. Method for determining surface properties of microparticles. United States: N. p., 2000. Web.
Eisenthal, Kenneth B. Method for determining surface properties of microparticles. United States.
Eisenthal, Kenneth B. Sat . "Method for determining surface properties of microparticles". United States. https://www.osti.gov/servlets/purl/872968.
@article{osti_872968,
title = {Method for determining surface properties of microparticles},
author = {Eisenthal, Kenneth B.},
abstractNote = {Second harmonic generation (SHG), sum frequency generation (SFG) and difference frequency generation (DFG) can be used for surface analysis or characterization of microparticles having a non-metallic surface feature. The microparticles can be centrosymmetric or such that non-metallic molecules of interest are centrosymmetrically distributed inside and outside the microparticles but not at the surface of the microparticles where the asymmetry aligns the molecules. The signal is quadratic in incident laser intensity or proportional to the product of two incident laser intensities for SFG, it is sharply peaked at the second harmonic wavelength, quadratic in the density of molecules adsorbed onto the microparticle surface, and linear in microparticles density. In medical or pharmacological applications, molecules of interest may be of drugs or toxins, for example.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2000},
month = {1}
}

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