Rapid method for measuring clastogenic fingerprints using fluorescence in situ hybridization
Abstract
A method is provided for determining a clastogenic signature of a sample of chromosomes by quantifying a frequency of a first type of chromosome aberration present in the sample; quantifying a frequency of a second, different type of chromosome aberration present in the sample; and comparing the frequency of the first type of chromosome aberration to the frequency of the second type of chromosome aberration. A method is also provided for using that clastogenic signature to identify a clastogenic agent or dosage to which the cells were exposed.
- Inventors:
-
- San Ramon, CA
- Issue Date:
- Research Org.:
- Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
- OSTI Identifier:
- 872929
- Patent Number(s):
- 6043037
- Assignee:
- Regents of University of California (Oakland, CA)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- DOE Contract Number:
- W-7405-ENG-48
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- rapid; method; measuring; clastogenic; fingerprints; fluorescence; situ; hybridization; provided; determining; signature; sample; chromosomes; quantifying; frequency; type; chromosome; aberration; comparing; identify; agent; dosage; cells; exposed; clastogenic signature; chromosome aberration; situ hybridization; rapid method; clastogenic agent; /435/436/
Citation Formats
Lucas, Joe N. Rapid method for measuring clastogenic fingerprints using fluorescence in situ hybridization. United States: N. p., 2000.
Web.
Lucas, Joe N. Rapid method for measuring clastogenic fingerprints using fluorescence in situ hybridization. United States.
Lucas, Joe N. Sat .
"Rapid method for measuring clastogenic fingerprints using fluorescence in situ hybridization". United States. https://www.osti.gov/servlets/purl/872929.
@article{osti_872929,
title = {Rapid method for measuring clastogenic fingerprints using fluorescence in situ hybridization},
author = {Lucas, Joe N},
abstractNote = {A method is provided for determining a clastogenic signature of a sample of chromosomes by quantifying a frequency of a first type of chromosome aberration present in the sample; quantifying a frequency of a second, different type of chromosome aberration present in the sample; and comparing the frequency of the first type of chromosome aberration to the frequency of the second type of chromosome aberration. A method is also provided for using that clastogenic signature to identify a clastogenic agent or dosage to which the cells were exposed.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Sat Jan 01 00:00:00 EST 2000},
month = {Sat Jan 01 00:00:00 EST 2000}
}
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