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Title: Process for the preparation of protected 3-amino-1,2-dihydroxypropane acetal and derivatives thereof

Abstract

A process for producing protected 3-amino-1,2-dihydroxypropane acetal, particularly in chiral forms, for use as an intermediate in the preparation of various 3-carbon compounds which are chiral. In particular, the present invention relates to the process for preparation of 3-amino-1,2-dihydroxypropane isopropylidene acetal. The protected 3-amino-1,2-dihydroxypropane acetal is a key intermediate to the preparation of chiral 3-carbon compounds which in turn are intermediates to various pharmaceuticals.

Inventors:
 [1];  [2]
  1. Haslett, MI
  2. East Lansing, MI
Issue Date:
Research Org.:
Michigan State Univ., East Lansing, MI (United States)
OSTI Identifier:
872924
Patent Number(s):
6040464
Assignee:
Board of Trustees operating Michigan State University (East Lansing, MI)
Patent Classifications (CPCs):
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07B - GENERAL METHODS OF ORGANIC CHEMISTRY
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07C - ACYCLIC OR CARBOCYCLIC COMPOUNDS
DOE Contract Number:  
FG02-89ER14029
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
process; preparation; protected; 3-amino-1; 2-dihydroxypropane; acetal; derivatives; producing; particularly; chiral; forms; intermediate; various; 3-carbon; compounds; particular; relates; isopropylidene; key; intermediates; pharmaceuticals; carbon compound; chiral form; carbon compounds; /999/

Citation Formats

Hollingsworth, Rawle I, and Wang, Guijun. Process for the preparation of protected 3-amino-1,2-dihydroxypropane acetal and derivatives thereof. United States: N. p., 2000. Web.
Hollingsworth, Rawle I, & Wang, Guijun. Process for the preparation of protected 3-amino-1,2-dihydroxypropane acetal and derivatives thereof. United States.
Hollingsworth, Rawle I, and Wang, Guijun. Sat . "Process for the preparation of protected 3-amino-1,2-dihydroxypropane acetal and derivatives thereof". United States. https://www.osti.gov/servlets/purl/872924.
@article{osti_872924,
title = {Process for the preparation of protected 3-amino-1,2-dihydroxypropane acetal and derivatives thereof},
author = {Hollingsworth, Rawle I and Wang, Guijun},
abstractNote = {A process for producing protected 3-amino-1,2-dihydroxypropane acetal, particularly in chiral forms, for use as an intermediate in the preparation of various 3-carbon compounds which are chiral. In particular, the present invention relates to the process for preparation of 3-amino-1,2-dihydroxypropane isopropylidene acetal. The protected 3-amino-1,2-dihydroxypropane acetal is a key intermediate to the preparation of chiral 3-carbon compounds which in turn are intermediates to various pharmaceuticals.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2000},
month = {1}
}

Works referenced in this record:

Membrane-enclosed enzymic catalysis (MEEC): a useful, practical new method for the manipulation of enzymes in organic synthesis
journal, February 1987


Synthese und Struktur diastereomerenreiner 2,6-disubstituierter 3-Morpholinone
journal, December 1988