Apparatus and method for performing microfluidic manipulations for chemical analysis and synthesis

Ramsey, J Michael

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A - human necessities
A01 - agriculture
A21 - baking
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A99 - subject matter not otherwise provided for in this section
B - performing operations
B01 - physical or chemical processes or apparatus in general
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Title: Apparatus and method for performing microfluidic manipulations for chemical analysis and synthesis

Abstract

A microchip laboratory system and method provide fluid manipulations for a variety of applications, including sample injection for microchip chemical separations. The microchip is fabricated using standard photolithographic procedures and chemical wet etching, with the substrate and cover plate joined using direct bonding. Capillary electrophoresis and electrochromatography are performed in channels formed in the substrate. Analytes are loaded into a four-way intersection of channels by electrokinetically pumping the analyte through the intersection, followed by switching of the potentials to force an analyte plug into the separation channel.

Inventors:

Ramsey, J Michael ^[1]

Knoxville, TN

Issue Date:: 2000-01-01

Research Org.:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

OSTI Identifier:: 872888

Patent Number(s):: 6033546

Assignee:: Lockheed Martin Energy Research Corporation (Oak Ridge, TN)

Patent Classifications (CPCs):: B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01D - SEPARATION

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01J - CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY

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B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01D - SEPARATION
B01D15/3842 - {Micellar chromatography}

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01J - CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY
B01J19/0093 - {Microreactors, e.g. miniaturised or microfabricated reactors
B01J2219/00783 - Laminate assemblies, i.e. the reactor comprising a stack of plates
B01J2219/00826 - Quartz
B01J2219/00828 - Silicon wafers or plates
B01J2219/00831 - Glass
B01J2219/00853 - Employing electrode arrangements
B01J2219/00889 - Mixing
B01J2219/00891 - Feeding or evacuation
B01J2219/00912 - by electrophoresis
B01J2219/00916 - by chromatography
B01J2219/00952 - Sensing operations
B01J2219/0097 - Optical sensors
B01J2219/00995 - Mathematical modeling

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
B01L2200/0605 - Metering of fluids
B01L2300/0816 - Cards, e.g. flat sample carriers usually with flow in two horizontal directions
B01L2300/0867 - Multiple inlets and one sample wells, e.g. mixing, dilution
B01L2300/0883 - Serpentine channels
B01L2400/0415 - electrical forces, e.g. electrokinetic
B01L2400/0418 - electro-osmotic flow [EOF]
B01L2400/0421 - electrophoretic flow
B01L3/5027 - {by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
B01L3/502715 - {characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces}
B01L3/50273 - {characterised by the means or forces applied to move the fluids
B01L3/502738 - {characterised by integrated valves
B01L3/502753 - {characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
B01L3/502776 - {specially adapted for focusing or laminating flows}
B01L3/502784 - {specially adapted for droplet or plug flow, e.g. digital microfluidics

B - PERFORMING OPERATIONS B29 - WORKING OF PLASTICS B29C - SHAPING OR JOINING OF PLASTICS
B29C65/4895 - {Solvent bonding, i.e. the surfaces of the parts to be joined being treated with solvents, swelling or softening agents, without adhesives}
B29C66/026 - {Chemical pre-treatments
B29C66/034 - {Thermal after-treatments}
B29C66/54 - {Joining several hollow-preforms, e.g. half-shells, to form hollow articles, e.g. for making balls, containers

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G01N2030/027 - {Liquid chromatography}
G01N2030/162 - {electromigration}
G01N2030/285 - {electrically driven carrier}
G01N2030/383 - {by using auxiliary fluid}
G01N2030/8435 - {for chemical reaction}
G01N27/44743 - {Introducing samples}
G01N27/44791 - {Microapparatus
G01N30/02 - Column chromatography
G01N30/16 - Injection
G01N30/6095 - {Micromachined or nanomachined, e.g. micro- or nanosize}

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10S - TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
Y10S366/01 - Micromixers

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DOE Contract Number:: AC05-84OR21400

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: apparatus; method; performing; microfluidic; manipulations; chemical; analysis; synthesis; microchip; laboratory; provide; fluid; variety; applications; including; sample; injection; separations; fabricated; standard; photolithographic; procedures; wet; etching; substrate; cover; plate; joined; direct; bonding; capillary; electrophoresis; electrochromatography; performed; channels; formed; analytes; loaded; four-way; intersection; electrokinetically; pumping; analyte; followed; switching; potentials; force; plug; separation; channel; chemical separations; separation channel; chemical wet; performing microfluidic; microfluidic manipulations; photolithographic procedures; plate joined; standard photolithographic; channels formed; chemical analysis; capillary electrophoresis; cover plate; sample injection; method provide; wet etching; provide fluid; microchip chemical; microchip laboratory; direct bonding; including sample; electrokinetically pumping; fluid manipulations; four-way intersection; analyte plug; chemical separation; fluidic manipulations; lithographic procedures; /204/435/

Citation Formats


                    Ramsey, J Michael. Apparatus and method for performing microfluidic manipulations for chemical analysis and synthesis.  United States: N. p., 2000. 
        Web.

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                    Ramsey, J Michael. Apparatus and method for performing microfluidic manipulations for chemical analysis and synthesis.  United States.

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                    Ramsey, J Michael. Sat .  
        "Apparatus and method for performing microfluidic manipulations for chemical analysis and synthesis".  United States.  https://www.osti.gov/servlets/purl/872888.

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@article{osti_872888,

  title        = {Apparatus and method for performing microfluidic manipulations for chemical analysis and synthesis},

  author       = {Ramsey, J Michael},

  abstractNote = {A microchip laboratory system and method provide fluid manipulations for a variety of applications, including sample injection for microchip chemical separations. The microchip is fabricated using standard photolithographic procedures and chemical wet etching, with the substrate and cover plate joined using direct bonding. Capillary electrophoresis and electrochromatography are performed in channels formed in the substrate. Analytes are loaded into a four-way intersection of channels by electrokinetically pumping the analyte through the intersection, followed by switching of the potentials to force an analyte plug into the separation channel.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2000},

  month        = {1}

}

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Works referenced in this record:

Electroosmosis: A Reliable Fluid Propulsion System for Flow Injection Analysis
journal, June 1994

Dasgupta, Purnendu K.; Liu, Shaorong.
Analytical Chemistry, Vol. 66, Issue 11
https://doi.org/10.1021/ac00083a004

Glass chips for high-speed capillary electrophoresis separations with submicrometer plate heights
journal, October 1993

Effenhauser, Carlo S.; Manz, Andreas.; Widmer, H. Michael.
Analytical Chemistry, Vol. 65, Issue 19
https://doi.org/10.1021/ac00067a015

Planar glass chips for capillary electrophoresis: repetitive sample injection, quantitation, and separation efficiency
journal, May 1993

Seiler, Kurt.; Harrison, D. Jed.; Manz, A.
Analytical Chemistry, Vol. 65, Issue 10
https://doi.org/10.1021/ac00058a029

Effects of Injection Schemes and Column Geometry on the Performance of Microchip Electrophoresis Devices
journal, April 1994

Jacobson, Stephen C.; Hergenroder, Roland.; Koutny, Lance B.
Analytical Chemistry, Vol. 66, Issue 7
https://doi.org/10.1021/ac00079a028

Micromachining of monocrystalline silicon and glass for chemical analysis systems A look into next century's technology or just a fashionable craze?
journal, May 1991

Manz, A.; Fettinger, J. C.; Verpoorte, E.
TrAC Trends in Analytical Chemistry, Vol. 10, Issue 5
https://doi.org/10.1016/0165-9936(91)85116-9

High-Speed Separations on a Microchip
journal, April 1994

Jacobson, Stephen C.; Hergenroder, Roland.; Koutny, Lance B.
Analytical Chemistry, Vol. 66, Issue 7
https://doi.org/10.1021/ac00079a029

Electric sample splitter for capillary zone electrophoresis
journal, February 1985

Deml, M.; Foret, F.; Boček, P.
Journal of Chromatography A, Vol. 320, Issue 1
https://doi.org/10.1016/S0021-9673(01)90491-1

Micromachining of capillary electrophoresis injectors and separators on glass chips and evaluation of flow at capillary intersections
journal, January 1994

Fan, Zhonghui H.; Harrison, D. Jed.
Analytical Chemistry, Vol. 66, Issue 1
https://doi.org/10.1021/ac00073a029

Micromachining a Miniaturized Capillary Electrophoresis-Based Chemical Analysis System on a Chip
journal, August 1993

Harrison, D. J.; Fluri, K.; Seiler, K.
Science, Vol. 261, Issue 5123
https://doi.org/10.1126/science.261.5123.895

Capillary electrophoresis and sample injection systems integrated on a planar glass chip
journal, September 1992

Harrison, D. Jed.; Manz, Andreas.; Fan, Zhonghui.
Analytical Chemistry, Vol. 64, Issue 17
https://doi.org/10.1021/ac00041a030

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Apparatus and method for performing microfluidic manipulations for chemical analysis and synthesis

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A microchip laboratory system and method provide fluid manipulations for a variety of applications, including sample injection for microchip chemical separations. The microchip is fabricated using standard photolithographic procedures and chemical wet etching, with the substrate and cover plate joined using direct bonding. Capillary electrophoresis and electrochromatography are performed in channels formed in the substrate. Analytes are loaded into a four-way intersection of channels by electrokinetically pumping the analyte through the intersection, followed by switching of the potentials to force an analyte plug into the separation channel.
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Similar Records

Title: Apparatus and method for performing microfluidic manipulations for chemical analysis and synthesis

Abstract

Citation Formats

Electroosmosis: A Reliable Fluid Propulsion System for Flow Injection Analysis journal, June 1994

Glass chips for high-speed capillary electrophoresis separations with submicrometer plate heights journal, October 1993

Planar glass chips for capillary electrophoresis: repetitive sample injection, quantitation, and separation efficiency journal, May 1993

Effects of Injection Schemes and Column Geometry on the Performance of Microchip Electrophoresis Devices journal, April 1994

Micromachining of monocrystalline silicon and glass for chemical analysis systems A look into next century's technology or just a fashionable craze? journal, May 1991

High-Speed Separations on a Microchip journal, April 1994

Electric sample splitter for capillary zone electrophoresis journal, February 1985

Micromachining of capillary electrophoresis injectors and separators on glass chips and evaluation of flow at capillary intersections journal, January 1994

Micromachining a Miniaturized Capillary Electrophoresis-Based Chemical Analysis System on a Chip journal, August 1993

Capillary electrophoresis and sample injection systems integrated on a planar glass chip journal, September 1992

Electroosmosis: A Reliable Fluid Propulsion System for Flow Injection Analysis
journal, June 1994

Glass chips for high-speed capillary electrophoresis separations with submicrometer plate heights
journal, October 1993

Planar glass chips for capillary electrophoresis: repetitive sample injection, quantitation, and separation efficiency
journal, May 1993

Effects of Injection Schemes and Column Geometry on the Performance of Microchip Electrophoresis Devices
journal, April 1994

Micromachining of monocrystalline silicon and glass for chemical analysis systems A look into next century's technology or just a fashionable craze?
journal, May 1991

High-Speed Separations on a Microchip
journal, April 1994

Electric sample splitter for capillary zone electrophoresis
journal, February 1985

Micromachining of capillary electrophoresis injectors and separators on glass chips and evaluation of flow at capillary intersections
journal, January 1994

Micromachining a Miniaturized Capillary Electrophoresis-Based Chemical Analysis System on a Chip
journal, August 1993

Capillary electrophoresis and sample injection systems integrated on a planar glass chip
journal, September 1992