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Title: Multiple-wavelength spectroscopic quantitation of light-absorbing species in scattering media

Abstract

An oxygen concentration measurement system for blood hemoglobin comprises a multiple-wavelength low-coherence optical light source that is coupled by single mode fibers through a splitter and combiner and focused on both a target tissue sample and a reference mirror. Reflections from both the reference mirror and from the depths of the target tissue sample are carried back and mixed to produce interference fringes in the splitter and combiner. The reference mirror is set such that the distance traversed in the reference path is the same as the distance traversed into and back from the target tissue sample at some depth in the sample that will provide light attenuation information that is dependent on the oxygen in blood hemoglobin in the target tissue sample. Two wavelengths of light are used to obtain concentrations. The method can be used to measure total hemoglobin concentration [Hb.sub.deoxy +Hb.sub.oxy ] or total blood volume in tissue and in conjunction with oxygen saturation measurements from pulse oximetry can be used to absolutely quantify oxyhemoglobin [HbO.sub.2 ] in tissue. The apparatus and method provide a general means for absolute quantitation of an absorber dispersed in a highly scattering medium.

Inventors:
 [1];  [2];  [3];  [4];  [5]
  1. Albany, CA
  2. Livermore, CA
  3. (Livermore, CA)
  4. Pleasanton, CA
  5. San Ramon, CA
Issue Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
OSTI Identifier:
872820
Patent Number(s):
6015969
Assignee:
Regents of University of California (Oakland, CA)
Patent Classifications (CPCs):
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
DOE Contract Number:  
W-7405-ENG-48
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
multiple-wavelength; spectroscopic; quantitation; light-absorbing; species; scattering; media; oxygen; concentration; measurement; blood; hemoglobin; comprises; low-coherence; optical; light; source; coupled; single; mode; fibers; splitter; combiner; focused; target; tissue; sample; reference; mirror; reflections; depths; carried; mixed; produce; interference; fringes; set; distance; traversed; path; depth; provide; attenuation; information; dependent; wavelengths; obtain; concentrations; method; measure; total; hb; deoxy; oxy; volume; conjunction; saturation; measurements; pulse; oximetry; absolutely; quantify; oxyhemoglobin; hbo; apparatus; means; absolute; absorber; dispersed; highly; medium; tissue sample; target tissue; highly scattering; mode fiber; oxygen concentration; light source; single mode; scattering medium; scattering media; method provide; optical light; concentration measurement; oxygen saturation; interference fringes; interference fringe; provide light; mode fibers; light attenuation; /250/356/

Citation Formats

Nathel, Howard, Cartland, Harry E, Colston, Jr., Billy W., Everett, Matthew J, and Roe, Jeffery N. Multiple-wavelength spectroscopic quantitation of light-absorbing species in scattering media. United States: N. p., 2000. Web.
Nathel, Howard, Cartland, Harry E, Colston, Jr., Billy W., Everett, Matthew J, & Roe, Jeffery N. Multiple-wavelength spectroscopic quantitation of light-absorbing species in scattering media. United States.
Nathel, Howard, Cartland, Harry E, Colston, Jr., Billy W., Everett, Matthew J, and Roe, Jeffery N. Sat . "Multiple-wavelength spectroscopic quantitation of light-absorbing species in scattering media". United States. https://www.osti.gov/servlets/purl/872820.
@article{osti_872820,
title = {Multiple-wavelength spectroscopic quantitation of light-absorbing species in scattering media},
author = {Nathel, Howard and Cartland, Harry E and Colston, Jr., Billy W. and Everett, Matthew J and Roe, Jeffery N},
abstractNote = {An oxygen concentration measurement system for blood hemoglobin comprises a multiple-wavelength low-coherence optical light source that is coupled by single mode fibers through a splitter and combiner and focused on both a target tissue sample and a reference mirror. Reflections from both the reference mirror and from the depths of the target tissue sample are carried back and mixed to produce interference fringes in the splitter and combiner. The reference mirror is set such that the distance traversed in the reference path is the same as the distance traversed into and back from the target tissue sample at some depth in the sample that will provide light attenuation information that is dependent on the oxygen in blood hemoglobin in the target tissue sample. Two wavelengths of light are used to obtain concentrations. The method can be used to measure total hemoglobin concentration [Hb.sub.deoxy +Hb.sub.oxy ] or total blood volume in tissue and in conjunction with oxygen saturation measurements from pulse oximetry can be used to absolutely quantify oxyhemoglobin [HbO.sub.2 ] in tissue. The apparatus and method provide a general means for absolute quantitation of an absorber dispersed in a highly scattering medium.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2000},
month = {1}
}

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