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Title: Detection of biological molecules using chemical amplification and optical sensors

Abstract

Methods are provided for the determination of the concentration of biological levels of polyhydroxylated compounds, particularly glucose. The methods utilize an amplification system that is an analyte transducer immobilized in a polymeric matrix, where the system is implantable and biocompatible. Upon interrogation by an optical system, the amplification system produces a signal capable of detection external to the skin of the patient. Quantitation of the analyte of interest is achieved by measurement of the emitted signal.

Inventors:
 [1];  [2]
  1. (Valencia, CA)
  2. (Los Angeles, CA)
Issue Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
OSTI Identifier:
872802
Patent Number(s):
6011984
Assignee:
Minimed Inc. (Sylmar, CA) LLNL
DOE Contract Number:  
W-7405-ENG-48
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
detection; biological; molecules; chemical; amplification; optical; sensors; methods; provided; determination; concentration; levels; polyhydroxylated; compounds; particularly; glucose; utilize; analyte; transducer; immobilized; polymeric; matrix; implantable; biocompatible; interrogation; produces; signal; capable; external; patient; quantitation; achieved; measurement; emitted; polymeric matrix; biological molecules; optical sensors; optical sensor; methods utilize; chemical amplification; particularly glucose; emitted signal; polyhydroxylated compounds; biological levels; /600/

Citation Formats

Van Antwerp, William Peter, and Mastrototaro, John Joseph. Detection of biological molecules using chemical amplification and optical sensors. United States: N. p., 2000. Web.
Van Antwerp, William Peter, & Mastrototaro, John Joseph. Detection of biological molecules using chemical amplification and optical sensors. United States.
Van Antwerp, William Peter, and Mastrototaro, John Joseph. Sat . "Detection of biological molecules using chemical amplification and optical sensors". United States. https://www.osti.gov/servlets/purl/872802.
@article{osti_872802,
title = {Detection of biological molecules using chemical amplification and optical sensors},
author = {Van Antwerp, William Peter and Mastrototaro, John Joseph},
abstractNote = {Methods are provided for the determination of the concentration of biological levels of polyhydroxylated compounds, particularly glucose. The methods utilize an amplification system that is an analyte transducer immobilized in a polymeric matrix, where the system is implantable and biocompatible. Upon interrogation by an optical system, the amplification system produces a signal capable of detection external to the skin of the patient. Quantitation of the analyte of interest is achieved by measurement of the emitted signal.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2000},
month = {1}
}

Patent:

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